Synthesis, X-Ray Powder Diffraction Studies and Antimicrobial Activities of Novel Chalcone Derivatives

Abstract

Schiff bases are an important class of organic compounds, which play and an important role in medicinal and pharmaceutical applications. The synthesized compounds, 1-(4-butoxy-2hydroxyphenyl) ethylidene-benzohydrazide (I), 1-(4-butoxy-2-hydroxy phenyl) ethylidene-4-chloro benzohydrazide (II) and 1-(4-butoxy-2-hydroxy phenyl) ethylidene-4-methyl benzohydrazide (III) have been characterized by FTIR, 1 H and 13 C NMR. The structural characterizations of synthesized compounds (I, II and III) have been estimated by analyzing powder X-ray diffraction technique. It is observed that samples I and III have crystallized in triclinic system with Pī space group and sample II in monoclinic system with P2 1 /n space group. The synthesized compounds have been screened for its antimicrobial and antifungal activities against different panel of organisms.