Synthesized bioactive lignin nanoparticles/polycaprolactone nanofibers: A novel nanobiocomposite for bone tissue engineering

Haider, Md. Kaiser; Kharaghani, Davood; Sun, Liangling; Ullah, Sana; Sarwar, Mohammad Nauman; Ullah, Azeem; Khatri, Muzamil; Yoshiko, Yuji; Gopiraman, Mayakrishnan; Kim, Ick Soo

doi:10.1016/j.bioadv.2022.213203

Cited by 34 publications

(16 citation statements)

References 87 publications

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“…They developed PCL nanofiber scaffolds with lignin nanoparticles and observed a significant improvement in osteogenic cell differentiation versus pure PCL scaffolds. They integrated the antibacterial and osteostimulative capacities of nanoparticles with the mechanical properties of PCL nanofibers, demonstrating the potential of this type of hybrid nanodevice for bone tissue engineering [ 63 ].…”

Section: Hybrid Systems For Control Of Reactive Oxygen Species For Ti...mentioning

confidence: 99%

Hybrid Systems of Nanofibers and Polymeric Nanoparticles for Biological Application and Delivery Systems

et al. 2023

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Nanomedicine is a new discipline resulting from the combination of nanotechnology and biomedicine. Nanomedicine has contributed to the development of new and improved treatments, diagnoses, and therapies. In this field, nanoparticles have notable importance due to their unique properties and characteristics, which are useful in different applications, including tissue engineering, biomarkers, and drug delivery systems. Electrospinning is a versatile technique used to produce fibrous mats. The high surface area of the electrospun mats makes them suitable for applications in fields using nanoparticles. Electrospun mats are used for tissue engineering, wound dressing, water-treatment filters, biosensors, nanocomposites, medical implants, protective clothing materials, cosmetics, and drug delivery systems. The combination of nanoparticles with nanofibers creates hybrid systems that acquire properties that differ from their components’ characteristics. By utilizing nanoparticles and nanofibers composed of dissimilar polymers, the two synergize to improve the overall performance of electrospinning mats and nanoparticles. This review summarizes the hybrid systems of polymeric nanoparticles and polymeric nanofibers, critically analyzing how the combination improves the properties of the materials and contributes to the reduction of some disadvantages found in nanometric devices and systems.

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Section: Hybrid Systems For Control Of Reactive Oxygen Species For Ti...mentioning

confidence: 99%

Hybrid Systems of Nanofibers and Polymeric Nanoparticles for Biological Application and Delivery Systems

et al. 2023

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“…A lactate dehydrogenase (LDH) assay using fibroblast cells (NIH3T3) was used to evaluate cell proliferation, following the procedures of previous study. 34 The NIH3T3 cells were cultured and incubated in a 5% CO 2 environment at 37 C for 30 min. Round disks made of nanofibrous mats were cut to a diameter of 6 mm and sterilized by immersion in 70% ethanol for 30 min.…”

Section: Nanofiber Characterizationmentioning

confidence: 99%

“…Cells and nanofibrous mats were incubated at 37 C with 5% CO 2 in a humidified incubator for 24 h. Based on the reported protocols, an LDH assay kit was used to measure cell proliferation at 490 nm using a microplate reader. 34 Cell proliferation was measured at intervals of 1, 3, 5, and 7 days.…”

Section: Nanofiber Characterizationmentioning

confidence: 99%

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Electrospun composite nanofibers of deoxyribonucleic acid and polylactic acid for skincare applications

Ullah

Ali

Hashmi

et al. 2023

J Biomedical Materials Res

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The development of useful biomaterials has resulted in significant advances in various fields of science and technology. The demand for new biomaterial designs and manufacturing techniques continues to grow, with the goal of building a sustainable society. In this study, two types of DNA‐cationic surfactant complexes were synthesized using commercially available deoxyribonucleic acid from herring sperm DNA (hsDNA, <50 bp) and deoxyribonucleic acid from salmon testes DNA (stDNA, ~2000 bp). The DNA‐surfactant complexes were blended with a polylactic acid (PLA) biopolymer and electrospun to obtain nanofibers, and then copper nanoparticles were synthesized on nanofibrous webs. Scanning electron microscopic images showed that all nanofibers possessed uniform morphology. Interestingly, different diameters were observed depending on the base pairs in the DNA complex. Transmission electron microscopy showed uniform growth of copper nanoparticles on the nanofibers. Fourier‐transform infrared spectroscopy spectra confirmed the uniform blending of both types of DNA complexes in PLA. Both stDNA‐ and hsDNA‐derived nanofibers showed greater biocompatibility than native PLA nanofibers. Furthermore, they exerted significant antibacterial activity in the presence of copper nanoparticles. This study demonstrates that DNA is a potentially useful material to generate electrospun nanofibrous webs for use in biomedical sciences and technologies.

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“…However, they are thermodynamically immiscible, resulting in a multiphase structure with poor dispersion and interfacial adhesion phase separation [ 9 ]. Up to now, various methods have been studied to improve the compatibility between phases in PLA/PCL blends, such as the addition of multi-block copolymers, reactive polymers, multi-functional polymeric compatibilizers, and fillers [ 18 , 19 , 20 , 21 ]. In this context, the use of natural reinforcements to improve the mechanical properties of biodegradable polymers for food packaging applications represents a promising method [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Almond Skin Waste and Glycidyl Methacrylate on Mechanical and Color Properties of Poly(ε-caprolactone)/Poly(lactic acid) Blends

et al. 2023

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Blending Poly(lactic acid) (PLA) and Poly(ε-caprolactone) (PCL) is a promising strategy to enhance the properties of biodegradable materials. However, these compounds are thermodynamically immiscible and, consequently, compatibilization is required during polymer blending. Reinforced biocomposites can be obtained by adding agricultural wastes generated by industries which are forced to consider waste treatment methods to prevent environmental concerns. Novel PCL/PLA blends were proposed based on the addition of 10 wt.% almond shell (AS) waste combined with 3 wt.% glycidyl methacrylate (GMA) as a compatibilizer. Different PCL-, PLA-, and PCL/PLA-based blends at different percentages (75:25, 50:50, 25:75, 15:85) added with GMA and AS were obtained. The color results highlighted the lower transparency and brownish tone of the studied formulations after the addition of AS. The addition of PCL provided a positive effect on PLA’s ductility due to its intrinsically higher flexibility. The combination of GMA and AS improved the mechanical properties of PCL, PLA, and 50:50 controls by reducing yield strength, yield strength at break, and elongation at break values. The 75:25_GMA_AS formulation showed a homogeneous visual appearance, low transparency, and desirable mechanical properties for rigid food packaging applications, reducing the final material cost through the revalorization of AS.

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Synthesized bioactive lignin nanoparticles/polycaprolactone nanofibers: A novel nanobiocomposite for bone tissue engineering

Cited by 34 publications

References 87 publications

Hybrid Systems of Nanofibers and Polymeric Nanoparticles for Biological Application and Delivery Systems

Hybrid Systems of Nanofibers and Polymeric Nanoparticles for Biological Application and Delivery Systems

Electrospun composite nanofibers of deoxyribonucleic acid and polylactic acid for skincare applications

Effect of Almond Skin Waste and Glycidyl Methacrylate on Mechanical and Color Properties of Poly(ε-caprolactone)/Poly(lactic acid) Blends

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