Synthesized pyridine compound derivatives decreased TNF alpha and adhesion molecules and ameliorated HSV-induced inflammation in a mouse model

Choi, Bunsoon; Kim, Joo-Hyon; Lee, Eun‐So; Bang, Dongsik; Sohn, Seonghyang

doi:10.1016/j.ejphar.2011.01.062

Cited by 9 publications

(6 citation statements)

References 36 publications

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“…Foxp3 has been shown to be a master regulator of Treg cell function (64), and the upregulation of Treg cells ameliorated inflammatory BD symptoms (65). TNFa downregulation correlated with an improvement in BD symptoms in mice (66) and patients (67).…”

Section: Discussionmentioning

confidence: 99%

Eubacterium rectale Attenuates HSV-1 Induced Systemic Inflammation in Mice by Inhibiting CD83

et al. 2021

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The purpose of this study was to determine whether administration of the microorganism Eubacterium rectale (E. rectale) could regulate dendritic cell (DC) activation and systemic inflammation in herpes simplex virus type 1-induced Behçet’s disease (BD). E. rectale, butyrate-producing bacteria, was administered to BD mice. Peripheral blood leukocytes (PBL) and lymph node cells were isolated and analyzed by flow cytometry. 16S rRNA metagenomic analysis was performed in the feces of mice to determine the differences in the composition of the microbial population between normal and BD mice. Serum cytokine levels were measured by enzyme-linked immunosorbent assay. The frequency of DC activation marker CD83 positive cells was significantly increased in PBL of BD mice. Frequencies of CD83+ cells were also significantly increased in patients with active BD. 16S rRNA metagenomic analysis revealed different gut microbiota composition between normal and BD mice. The administration of E. rectale to BD mice reduced the frequency of CD83+ cells and significantly increased the frequency of NK1.1+ cells with the improvement of symptoms. The co-administration of colchicine and E. rectale also significantly reduced the frequency of CD83+ cells. Differences in gut microbiota were observed between normal mice and BD mice, and the administration of E. rectale downregulated the frequency of CD83, which was associated with BD deterioration. These data indicate that E. rectale could be a new therapeutic adjuvant for BD management.

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Section: Discussionmentioning

confidence: 99%

Eubacterium rectale Attenuates HSV-1 Induced Systemic Inflammation in Mice by Inhibiting CD83

et al. 2021

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“…SK126 and SK94 are synthesized pyridine derivatives based on gentianine, a major component of Gentiana Macrophylla Radix. When SK126 and SK94 were used to treat TNFα-stimulated human umbilical vein endothelial cells, they down-regulated adhesion molecules such as ICAM-1, VCAM-1, and E-selectin [ 40 ]. In addition, oral administration of SK126 and SK94 effectively down-regulated serum levels of TNFα in HSV-induced BD mice accompanied by symptom improvement [ 40 ] ( Figure 1 ).…”

Section: Therapeutic Applications Of Inflammatory Mice Model Of Bementioning

confidence: 99%

HSV-Induced Systemic Inflammation as an Animal Model for Behçet’s Disease and Therapeutic Applications

Islam

Sohn

2018

Viruses

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Behçet’s disease (BD) affects multiple organs. It is mainly characterized by recurrent oral, skin, and genital aphthous ulcers, and eye involvement. Successful management of BD is increasing, although its etiology remains unclear. A number of etiologies have been proposed, including environmental, genetic, viral, and immunological factors. To understand its complex etiology and improve its management, animal models of BD have been used to enable more effective therapeutic applications with increased clinical significance. An herpes simplex virus (HSV) type 1-induced BD mouse model has shown disease characteristics similar to those seen in BD patients. An HSV-induced BD animal model has been used to test various therapeutic modalities. The applied modalities are several materials that are derived from natural products, conventional therapeutics, and possible biologics. In this review, we provided how they regulate inflammation in an HSV-induced BD model.

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“…The TNF- α blockers infliximab and etanercept have both been shown to reduce serum concentrations of soluble ICAM-1 and E-selectin in patients with arthritis [30, 31]. As well, a synthesized pyridine compound derivative (SK94) downregulated E-selectin, VCAM-1, and ICAM-1 in the HSV-induced BD mouse model [32]. Together with TNF- α inhibitors, targeting HSV-induced cell adhesion molecules on endothelial cells may thus be a promising therapeutic strategy for BD.…”

Section: The Effect Of Hsv Infection On the Expression Of Cell Adhmentioning

confidence: 99%

“…Injecting TNF- α small interfering RNA or anti-TNF- α blockades (infliximab or etanercept) inhibited TNF- α gene expression and improved symptoms in a BD mouse model [39]. Synthesized pyridine compound derivatives (SK94 and SK126) are also potential therapeutic candidates for BD, as they have been shown to downregulate cell adhesion molecules and TNF- α , and ameliorate symptoms in the BD mouse model [32]. …”

Section: Therapeutic Efficacy Of Hsv-targeted Treatments In Bd Patmentioning

confidence: 99%

Immunopathogenic Role of Herpes Simplex Virus in Behçet’s Disease

Kim

Cho

Choi

et al. 2013

Genetics Research International

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The role of viral infections, such as herpes simplex virus (HSV) infection, in the pathogenesis of Behçet's disease (BD) has been investigated for many years. HSV has been detected in peripheral blood leukocytes, saliva, and genital ulcers of patients with BD. Various cell adhesion molecules on cultured endothelial cells have been induced by HSV in a TNF-α dependent manner. In addition, a BD-like animal model was developed by inoculating ICR mouse earlobes with HSV, and antiviral treatment was effective in improving BD-like symptoms in this model. Still, there are several incompletely characterized proteins that possess antiviral properties and are being investigated as mediators of viral infection-related chronic inflammatory reactions. Although the role of HSV in the pathogenesis of BD remains to be fully established, recent research findings regarding HSV in BD have expanded our understanding of the disease and will hopefully lead to the development of more effective therapeutic agents in the near future.

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Synthesized pyridine compound derivatives decreased TNF alpha and adhesion molecules and ameliorated HSV-induced inflammation in a mouse model

Cited by 9 publications

References 36 publications

Eubacterium rectale Attenuates HSV-1 Induced Systemic Inflammation in Mice by Inhibiting CD83

Eubacterium rectale Attenuates HSV-1 Induced Systemic Inflammation in Mice by Inhibiting CD83

HSV-Induced Systemic Inflammation as an Animal Model for Behçet’s Disease and Therapeutic Applications

Immunopathogenic Role of Herpes Simplex Virus in Behçet’s Disease

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