Synthesizing a multifunctional polymer to construct the catalytically NO-generating coating for improving corrosion resistance and biocompatibility of the magnesium alloy stent materials

Chen, Jie; Liu, Xuhui; Hong, Qingxiang; Meng, Lingjie; Ji, Yan; Wang, Lingtao; Zhang, Qiuyang; Lin, Jiafeng; Pan, Changjiang

doi:10.1016/j.porgcoat.2023.108058

Cited by 5 publications

(1 citation statement)

References 63 publications

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“…The biomolecular coating modified on the surface of biomedical materials is a direct contact site for cell adhesion and growth on the material surface, which has a significant impact on human physiological activities [1][2][3][4][5][6]. Numerous in vivo and in vitro animal experiments have shown that Mg alloy materials modified with functional biomolecular coatings have good biocompatibility, biomechanical compatibility, antibacterial properties, and appropriate corrosion resistance performance [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Interaction Regularity of Biomolecules on Mg and Mg-Based Alloy Surfaces: A First-Principles Study

Fang,

Ma,

Liang

et al. 2023

Coatings

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Adsorbed molecules can modulate the behavior of magnesium (Mg) and Mg alloy in biomedical applications. The interaction regularity and mechanism of biomolecules (such as amino acids, dipeptides, and tripeptide) on a Mg(0001) surface, the influence of dipole correction, and the effects of alloying elements and electronic structure were investigated in this study using first-principles calculations. Specifically, the adsorption energy (Eads) of functional groups (-NH2, -COOH and -CN3H4), amino acids (arginine (Arg), glycine (Gly), and aspartic acid (Asp)), dipeptides (arginine–glycine (Arg-Gly), glycine–aspartic acid (Gly-Asp), and arginine–aspartic acid (Arg-Asp)), and arginine–glycine–aspartic acid (RGD) tripeptide were systematically calculated. Dipole correction slightly enhanced the interaction between molecules and Mg surfaces, but the Eads trend remained unchanged. The addition of alloying elements improved the interaction of molecules and Mg-based alloy surfaces. This study will be of fundamental importance in understanding the interaction regularity of molecules on Mg and Mg-based alloy surfaces and provide possibilities for surface modification design of biomedical materials.

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Section: Introductionmentioning

confidence: 99%

Interaction Regularity of Biomolecules on Mg and Mg-Based Alloy Surfaces: A First-Principles Study

Fang,

Ma,

Liang

et al. 2023

Coatings

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Hydrogen‐Generating Magnesium Alloy Seed Strand Sensitizes Solid Tumors to Iodine‐125 Brachytherapy

Hu,

Lin,

Chen

et al. 2024

Advanced Science

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Radioactive iodine‐125 (125I) seed implantation, a brachytherapy technique, effectively kills tumor cells via X‐rays and gamma rays, serving as an alternative therapeutic option following the failure of frontline treatments for various solid tumors. However, tumor radioresistance limits its efficacy. Hydrogen gas has anticancer properties and can enhance the efficacy of immunotherapy. However, its role in radiotherapy sensitization has rarely been reported. Many current hydrogen delivery methods involve hydrogen‐generating nanomaterials, such as magnesium‐based nanomaterials. This study introduces an AZ31 magnesium alloy 125I seed strand (termed AMASS) with pH‐dependent slow‐release hydrogen characteristics and excellent mechanical properties. AMASS can be implanted into tumors via minimally invasive surgery, releasing hydrogen around the 125I seeds. In vitro experiments showed that hydrogen from AMASS degradation significantly inhibited tumor proliferation, increased apoptosis, disrupted redox homeostasis and mitochondrial membrane potential, reduced adenosine triphosphate levels, and induced DNA damage due to 125I radiation. In mouse xenograft and rabbit liver tumor models, hydrogen from AMASS showed superior therapeutic effects compared with 125I seeds alone, with no noticeable side effects. In addition, AMASS has a uniform radiation dose distribution and simple implantation. Therefore, hydrogen from AMASS enhanced 125I seed efficacy, supporting the further promotion and application of 125I seed implantation in cancer therapy.

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A study on combination of alkaline treatment and PLA/f-CNTs composite coating on corrosion, biocompatibility and antibacterial activity of Mg alloy

Abrari,

Ahmadi,

Nekouie

et al. 2024

Materials Today Communications

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Synthesizing a multifunctional polymer to construct the catalytically NO-generating coating for improving corrosion resistance and biocompatibility of the magnesium alloy stent materials

Cited by 5 publications

References 63 publications

Interaction Regularity of Biomolecules on Mg and Mg-Based Alloy Surfaces: A First-Principles Study

Interaction Regularity of Biomolecules on Mg and Mg-Based Alloy Surfaces: A First-Principles Study

Hydrogen‐Generating Magnesium Alloy Seed Strand Sensitizes Solid Tumors to Iodine‐125 Brachytherapy

A study on combination of alkaline treatment and PLA/f-CNTs composite coating on corrosion, biocompatibility and antibacterial activity of Mg alloy

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