Synthetic Access to gem-Difluoropropargyl Vinyl Ethers and Their Application to Propargyl Claisen Rearrangement

Abstract

With the increasing importance of fluorine to medicinal chemistry and other areas, methods to access various fluorinated compounds are needed. Herein, we report the synthesis of difluoropropargyl vinyl ethers from ketones and aldehydes using difluoropropargyl bromide dicobalt complexes. We applied difluoropropargyl vinyl ethers to the synthesis of difluorodienone or difluoroallene under thermal conditions and trifluoro-pyran under acid-catalyzed conditions.

Highly dispersed Cs2O/SiO2 catalysts for selective intramolecular dehydration of ethylene glycol monoethyl ether to ethyl vinyl ether

“…Besides, vinyl ethers can also serve as monomers in polymer chemistry. [1][2][3][4] Accordingly, vinyl ethers are widely applied in adhesives, paints, oil viscosity modifiers and vinyl polymer materials. [5][6][7][8] The preparation of vinyl ethers was first reported by Wislicenus in 1878 via the elimination of monochloracetal catalyzed by sodium.…”

“…Besides, vinyl ethers can also serve as monomers in polymer chemistry. 1–4 Accordingly, vinyl ethers are widely applied in adhesives, paints, oil viscosity modifiers and vinyl polymer materials. 5–8…”