“…We synthesized the compounds C-V (Cys-Val-Val-Tyr-Pro-Trp-Thr-Glu), H-V (His-Val-Val-Tyr-Pro-Trp-Thr-Glu), AC-V (Adam-Cys-Val-Val-Tyr-Pro-Trp-Thr-Glu), and AH-V (Adam-His-Val-Val-Tyr-Pro-Trp-Thr-Glu) by replacement of the glutamine (Gln) at the C-terminus with glutamic acid (Glu), first to estimate the influence of Gln on the antimicrobial activity of the peptides, and second the binding of the peptide molecules to the textile material. Aiming to additionally prove the importance of adamantane group and antiviral potency, we introduced the 1-adamantanecarboxylic acid to the N-side, and also amino acids Cys and His of VV-hemorphin-5 to obtain the peptides C-V, H-V, AC-V, and AH-V. Adamantane-containing compounds have long been proven antiviral agents which are currently used in clinical practice: amantadine, rimantadine, and tromantadine [ 35 , 36 , 37 ]. In their attempts to find an effective way to fight the pandemic situation of COVID-19, scientists are currently synthesizing new biomolecules, as the numerous compounds containing adamantane are constantly increasing.…”