2020
DOI: 10.1007/s00726-020-02914-4
|View full text |Cite
|
Sign up to set email alerts
|

Synthetic analogues of memantine as neuroprotective and influenza viral inhibitors: in vitro and physicochemical studies

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
8
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
6
1

Relationship

0
7

Authors

Journals

citations
Cited by 8 publications
(8 citation statements)
references
References 54 publications
0
8
0
Order By: Relevance
“…We synthesized the compounds C-V (Cys-Val-Val-Tyr-Pro-Trp-Thr-Glu), H-V (His-Val-Val-Tyr-Pro-Trp-Thr-Glu), AC-V (Adam-Cys-Val-Val-Tyr-Pro-Trp-Thr-Glu), and AH-V (Adam-His-Val-Val-Tyr-Pro-Trp-Thr-Glu) by replacement of the glutamine (Gln) at the C-terminus with glutamic acid (Glu), first to estimate the influence of Gln on the antimicrobial activity of the peptides, and second the binding of the peptide molecules to the textile material. Aiming to additionally prove the importance of adamantane group and antiviral potency, we introduced the 1-adamantanecarboxylic acid to the N-side, and also amino acids Cys and His of VV-hemorphin-5 to obtain the peptides C-V, H-V, AC-V, and AH-V. Adamantane-containing compounds have long been proven antiviral agents which are currently used in clinical practice: amantadine, rimantadine, and tromantadine [ 35 , 36 , 37 ]. In their attempts to find an effective way to fight the pandemic situation of COVID-19, scientists are currently synthesizing new biomolecules, as the numerous compounds containing adamantane are constantly increasing.…”
Section: Resultsmentioning
confidence: 99%
“…We synthesized the compounds C-V (Cys-Val-Val-Tyr-Pro-Trp-Thr-Glu), H-V (His-Val-Val-Tyr-Pro-Trp-Thr-Glu), AC-V (Adam-Cys-Val-Val-Tyr-Pro-Trp-Thr-Glu), and AH-V (Adam-His-Val-Val-Tyr-Pro-Trp-Thr-Glu) by replacement of the glutamine (Gln) at the C-terminus with glutamic acid (Glu), first to estimate the influence of Gln on the antimicrobial activity of the peptides, and second the binding of the peptide molecules to the textile material. Aiming to additionally prove the importance of adamantane group and antiviral potency, we introduced the 1-adamantanecarboxylic acid to the N-side, and also amino acids Cys and His of VV-hemorphin-5 to obtain the peptides C-V, H-V, AC-V, and AH-V. Adamantane-containing compounds have long been proven antiviral agents which are currently used in clinical practice: amantadine, rimantadine, and tromantadine [ 35 , 36 , 37 ]. In their attempts to find an effective way to fight the pandemic situation of COVID-19, scientists are currently synthesizing new biomolecules, as the numerous compounds containing adamantane are constantly increasing.…”
Section: Resultsmentioning
confidence: 99%
“…Each well was inoculated with 100 µL dilutions. The cytopathic effect (CPE) was recorded and observed every day, and the virus titer was counted using the Reed−Muench method [ 31 ].…”
Section: Methodsmentioning
confidence: 99%
“…76 Therefore, studying some of the most important physicochemical characteristics such as pK a , pI, distribution coefficients (log P), and heterogeneous rate constants would help understand their biochemical and biophysical properties. Given that the oxidative-reductive behavior of peptides is directly related, for example, with neuropathological processes, 77 electron/proton transfer of different peptide sequences was also studied.…”
Section: Physicochemical Characterizationmentioning
confidence: 99%
“…Log P values usually vary from À2 to +12 and can be determined by different methods such as electrochemical, chromatographic, spectrochemical etc. 77,79 As a general rule, substances with a high logP will have a low solubility in water. Log P values in the range of À2 to 4 (in some cases up to 5 and more) can be experimentally determined by the most commonly used method: ''the shakeflask method''.…”
Section: Determination Of Coefficients Of Distribution (Log P)mentioning
confidence: 99%
See 1 more Smart Citation