Synthetic and biological identities of polymeric nanoparticles influencing the cellular delivery: An immunological link

Rezaei, Ghassem; Daghighi, Seyed Mojtaba; Raoufi, Mohammad; Esfandyari-Manesh, Mehdi; Rahimifard, Mahban; Mobarakeh, Vahid Iranpur; Kamalzare, Sara; Ghahremani, Mohammad Hossein; Atyabi, Fatemeh; Abdollahi, Mohammad; Rezaee, Farhad; Dinarvand, Rassoul

doi:10.1016/j.jcis.2019.08.060

Cited by 23 publications

(14 citation statements)

References 74 publications

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“…In another study, it was shown that clinical and preclinical NPs are recognized by “natural” pre-existing antibodies and that labeling of NP-bound IgG by C3b/iC3b opsonins is crucial for an effective capture by phagocytes ( 69 ). The use of FcR-negative or overexpressing cell lines also indirectly suggested that NP-bound antibodies mediate cell interaction with phagocytes ( 41 , 70 ).…”

Section: Influence On Np-cell Interactions Of Specific Np-bound Protementioning

confidence: 99%

Opsonins and Dysopsonins of Nanoparticles: Facts, Concepts, and Methodological Guidelines

2020

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Understanding the effects mediated by a set of nanoparticle (NP)-bound host biomolecules, often indicated with the umbrella term of NP corona , is essential in nanomedicine, nanopharmacology, and nanotoxicology. Among the NP-adsorbed proteome , some factors mediate cell binding, endocytosis, and clearing by macrophages and other phagocytes (opsonins), while some others display few affinities for the cell surface (dysopsonins). The functional mapping of opsonins and dysopsonins is instrumental to design long-circulating and nanotoxicologically safe next-generation nanotheranostics. In this review, we critically analyze functional data identifying specific proteins with opsonin or dysopsonin properties. Special attention is dedicated to the following: (1) the simplicity or complexity of the NP proteome and its modulation, (2) the role of specific host proteins in mediating the stealth properties of uncoated or polymer-coated NPs, and (3) the ability of the innate immune system, and, in particular, of the complement proteins, to mediate NP clearance by phagocytes. Emerging species-specific peculiarities, differentiating humans from preclinical animal models (the murine especially), are highlighted throughout this overview. The operative definition of opsonin and dysopsonin and the measurement schemes to assess their in vitro efficacy is critically re-examined. This provides a shared and unbiased approach useful for NP opsonin and dysopsonin systematic identification.

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Section: Influence On Np-cell Interactions Of Specific Np-bound Protementioning

confidence: 99%

Opsonins and Dysopsonins of Nanoparticles: Facts, Concepts, and Methodological Guidelines

2020

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“…Rezai et al demonstrated that PVA-PLGA-NPs are internalized differently depending on dysopsonin/opsonin abundance in the protein corona. Higher opsonin proportion favored FcR-dependent internalization, while in FcRcells, opsonins hampered nanoparticle internalization [27]. This ratio between dysopsonin and opsonin could, therefore, be key not only for prolonging NP circulation, but could also be manipulated to improve targeting towards a particular cell type or even a subcellular compartment.…”

Section: Endocytosis and Ionp Degradationmentioning

confidence: 99%

The Intrinsic Biological Identities of Iron Oxide Nanoparticles and Their Coatings: Unexplored Territory for Combinatorial Therapies

2020

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Over the last 20 years, iron oxide nanoparticles (IONPs) have been the subject of increasing investigation due to their potential use as theranostic agents. Their unique physical properties (physical identity), ample possibilities for surface modifications (synthetic identity), and the complex dynamics of their interaction with biological systems (biological identity) make IONPs a unique and fruitful resource for developing magnetic field-based therapeutic and diagnostic approaches to the treatment of diseases such as cancer. Like all nanomaterials, IONPs also interact with different cell types in vivo, a characteristic that ultimately determines their activity over the short and long term. Cells of the mononuclear phagocytic system (macrophages), dendritic cells (DCs), and endothelial cells (ECs) are engaged in the bulk of IONP encounters in the organism, and also determine IONP biodistribution. Therefore, the biological effects that IONPs trigger in these cells (biological identity) are of utmost importance to better understand and refine the efficacy of IONP-based theranostics. In the present review, which is focused on anti-cancer therapy, we discuss recent findings on the biological identities of IONPs, particularly as concerns their interactions with myeloid, endothelial, and tumor cells. Furthermore, we thoroughly discuss current understandings of the basic molecular mechanisms and complex interactions that govern IONP biological identity, and how these traits could be used as a stepping stone for future research.

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“…The presence of the protein corona inhibited the phagocytosis of PLGA nanoparticles by Raw 264.7 cells. Studies have shown that the role of the protein corona in biological systems can be divided into "opsonins" and "dysopsonins" [41] . Opsonins promote macrophage phagocytosis, while dysopsonins inhibit phagocytosis.…”

Section: Discussionmentioning

confidence: 99%

Phagocytosis of Polymeric Nanoparticles Aided Activation of Macrophages to Induce Atherosclerotic Plaques in Apoe-/- Mice 

Yin

Atik

et al. 2020

Preprint

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The unique physiochemical properties of nanomaterials have been widely used in drug delivery systems and diagnostic contrast agents. The safety issues of biomaterials with exceptional biocompatibility and hemo-compatibility have also received extensive attention at the nanoscale, especially in cardiovascular disease. Therefore, we conducted a study of the effects of poly (lactic-co-glycolic acid) nanoparticles (PLGA NPs) on the development of aortic atherosclerotic plaques in ApoE-/- mice. The particle size of PLGA NPs was 92.69 ± 3.1 nm and the zeta potential were -31.6 ± 2.8 mV, with good blood compatibility. ApoE-/- mice were continuously injected with PLGA NPs intravenously for 4 and 12 weeks. Examination of oil red O stained aortic sinuses confirmed that the accumulation of PLGA NPs promoted the formation of atherosclerotic plaques and increasing the expression of associated inflammatory factors, such as TNF-α, IL-6, and IL-10. The combined exposure of ox-LDL and PLGA NPs accelerated the conversion of macrophages to foam cells. Our results highlight the potential risk for PLGA NPs in vivo and further understanding the interaction between PLGA NPs and the atherosclerotic plaques, which we should consider in future nanomaterial design and pay more attention to the process of using nano-medicines on cardiovascular diseases.

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Synthetic and biological identities of polymeric nanoparticles influencing the cellular delivery: An immunological link

Cited by 23 publications

References 74 publications

Opsonins and Dysopsonins of Nanoparticles: Facts, Concepts, and Methodological Guidelines

Opsonins and Dysopsonins of Nanoparticles: Facts, Concepts, and Methodological Guidelines

The Intrinsic Biological Identities of Iron Oxide Nanoparticles and Their Coatings: Unexplored Territory for Combinatorial Therapies

Phagocytosis of Polymeric Nanoparticles Aided Activation of Macrophages to Induce Atherosclerotic Plaques in Apoe-/- Mice

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Synthetic and biological identities of polymeric nanoparticles influencing the cellular delivery: An immunological link

Cited by 23 publications

References 74 publications

Opsonins and Dysopsonins of Nanoparticles: Facts, Concepts, and Methodological Guidelines

Opsonins and Dysopsonins of Nanoparticles: Facts, Concepts, and Methodological Guidelines

The Intrinsic Biological Identities of Iron Oxide Nanoparticles and Their Coatings: Unexplored Territory for Combinatorial Therapies

Phagocytosis of Polymeric Nanoparticles Aided Activation of Macrophages to Induce Atherosclerotic Plaques in Apoe-/- Mice&nbsp;

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Phagocytosis of Polymeric Nanoparticles Aided Activation of Macrophages to Induce Atherosclerotic Plaques in Apoe-/- Mice