Synthetic anticonvulsants, antihypoxics, and inducers of the liver monooxygenase system based on amides and urea. XV. Synthesis and biological activity of newortho-substituted benzhydrylureas: Potential synthones of quinazolines and benzodiazepines

Бакибаев, А. А.; Gorshkova, V. K.; Tignibidina, L. G.; Shtrykova, V. V.; Филимонов, В. Д.; Saratikov, A. S.

doi:10.1007/bf02219245

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“…At study of more than 40 derivatives of quinazolines, some qualitative correlations between structure and convulsive activity were revealed [15,16]. Transition from 3-aryl-to 3-alkylquinazolones-4 saves the sedative, hypnotic, and anticonvulsant properties of compounds [16]. The last type of activity is also characterized for 2-methyl-3-piperazino-alkylquinazolones-4.…”

Section: Introductionmentioning

confidence: 99%

Introductory Chapter: The Newest Research in Quinazolinone and Quinazoline Derivatives

Al-kaf¹

2020

Quinazolinone and Quinazoline Derivatives

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Section: Introductionmentioning

confidence: 99%

Introductory Chapter: The Newest Research in Quinazolinone and Quinazoline Derivatives

Al-kaf¹

2020

Quinazolinone and Quinazoline Derivatives

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Synthesis and Properties of a Water-Soluble Ureide Derived from Gаlodif and Succinic Acid

Kuksenok,

Cui,

Shtrykova

et al. 2023

Russ J Org Chem

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Synthesis and discovery of a water-soluble ureid of galodif with succinic acid

Kuksenok,

Cui,

Shtrykova

et al. 2023

Žurnal organičeskoj himii

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For the first time, a new acyl ureide of the anticonvulsant and anti-alcohol drug galodif (3-chlorobenzhydryl urea) with succinic acid was obtained and studied. The synthesis was carried out by the acylation of galodif with succinic anhydride in presence of certain acids. Unlike galodif, which is practically insoluble in water, the resulting benzhydryl ureide is soluble in aqueous media and can potentially exhibit greater bioavailability and can be used as a liquid dosage form and prodrug with prolonged action.

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Synthetic anticonvulsants, antihypoxics, and inducers of the liver monooxygenase system based on amides and urea. XV. Synthesis and biological activity of newortho-substituted benzhydrylureas: Potential synthones of quinazolines and benzodiazepines

Cited by 3 publications

References 0 publications

Introductory Chapter: The Newest Research in Quinazolinone and Quinazoline Derivatives

Introductory Chapter: The Newest Research in Quinazolinone and Quinazoline Derivatives

Synthesis and Properties of a Water-Soluble Ureide Derived from Gаlodif and Succinic Acid

Synthesis and discovery of a water-soluble ureid of galodif with succinic acid

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