Synthetic Antimicrobial Peptide Polybia MP-1 (Mastoparan) Inhibits Growth of Antibiotic Resistant Pseudomonas aeruginosa Isolates From Mastitic Cow Milk

Shah, Pallavi; Shrivastava, Sameer; Singh, Rajkumar James; Gogoi, Purnima; Saxena, Sonal; Srivastava, Saumya; Kumar, Naveen; Gaur, Gyanendra Kumar

doi:10.1007/s10989-021-10266-0

Cited by 5 publications

(4 citation statements)

References 55 publications

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“…Tomasinsig et al [ 83 ] reported in their study that cathelicidins, a class of peptides derived from bovine sources, including BMAP-27, BMAP-28, Bac5, and indolicidin, had a wide range of effectiveness (MIC = 0.5–32 µM) against a majority of bacterial isolates [ 83 ]. Shah et al [ 84 ] examined the antimicrobial and antibiofilm activity of Polybia MP-1 (Mastoparan) peptide derived from the venom of the vespid wasp Polybia paulista against multi-drug resistant P. aeruginosa from bovine mastitis. The Polybia MP 1 demonstrated efficacy against tested pathogens with MICs of 75 µM and MBCs of 150 µM, according to the study's findings.…”

Section: Alternatives Options For Mastitis Treatmentmentioning

confidence: 99%

“…The Polybia MP 1 demonstrated efficacy against tested pathogens with MICs of 75 µM and MBCs of 150 µM, according to the study's findings. Furthermore, Polybia MP-1 demonstrated very low to moderate hemolytic activity against red blood cells (RBCs) of goat, cow, and buffalodue to its strong membrane selectivity [ 84 ].…”

Section: Alternatives Options For Mastitis Treatmentmentioning

confidence: 99%

“…In addition to their direct antimicrobial activity, AMPs possess immunomodulatory properties, which stimulate the immune reaction of the host animal. By stimulating the functioning of immune cells and enhancing their functionality, AMPs contribute to a higher and effective protection against bacterial invaders [ 84 , 86 ]. In an era of increasing antibiotic resistance, AMPs are emerging as a potent and promising therapeutic alternative.…”

Section: Alternatives Options For Mastitis Treatmentmentioning

confidence: 99%

See 2 more Smart Citations

Confronting the complexities of antimicrobial management for Staphylococcus aureus causing bovine mastitis: an innovative paradigm

Saeed,

Kamaruzzaman,

Gahamanyi

et al. 2024

Ir Vet J

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Globally, Mastitis is a disease commonly affecting dairy cattle which leads to the use of antimicrobials. The majority of mastitis etiological agents are bacterial pathogens and Staphylococcus aureus is the predominant causative agent. Antimicrobial treatment is administered mainly via intramammary and intramuscular routes. Due to increasing antimicrobial resistance (AMR) often associated with antimicrobial misuse, the treatment of mastitis is becoming challenging with less alternative treatment options. Besides, biofilms formation and ability of mastitis-causing bacteria to enter and adhere within the cells of the mammary epithelium complicate the treatment of bovine mastitis. In this review article, we address the challenges in treating mastitis through conventional antibiotic treatment because of the rising AMR, biofilms formation, and the intracellular survival of bacteria. This review article describes different alternative treatments including phytochemical compounds, antimicrobial peptides (AMPs), phage therapy, and Graphene Nanomaterial-Based Therapy that can potentially be further developed to complement existing antimicrobial therapy and overcome the growing threat of AMR in etiologies of mastitis.

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Section: Alternatives Options For Mastitis Treatmentmentioning

confidence: 99%

Section: Alternatives Options For Mastitis Treatmentmentioning

confidence: 99%

Section: Alternatives Options For Mastitis Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Confronting the complexities of antimicrobial management for Staphylococcus aureus causing bovine mastitis: an innovative paradigm

Saeed,

Kamaruzzaman,

Gahamanyi

et al. 2024

Ir Vet J

View full text Add to dashboard Cite

show abstract

“…Polybia MP-1, a 14-amino acid AMP from wasp venom, was bactericidal against multidrug-resistant S. aureus , E. coli and K. pneumoniae strains from bovine mastitis ( 25 , 35 ). Esculentin 1–21, an AMP from frog skin, had broad-spectrum antimicrobial activity ( 86 ), particularly against Pseudomonas aeruginosa , E. coli , and S. agalactiae in vivo and in vitro ( 87 ).…”

Section: Antimicrobial Peptides Therapymentioning

confidence: 99%

Alternatives to antibiotics for treatment of mastitis in dairy cows

Liang

et al. 2023

Front. Vet. Sci.

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Mastitis is considered the costliest disease on dairy farms and also adversely affects animal welfare. As treatment (and to a lesser extent prevention) of mastitis rely heavily on antibiotics, there are increasing concerns in veterinary and human medicine regarding development of antimicrobial resistance. Furthermore, with genes conferring resistance being capable of transfer to heterologous strains, reducing resistance in strains of animal origin should have positive impacts on humans. This article briefly reviews potential roles of non-steroidal anti-inflammatory drugs (NSAIDs), herbal medicines, antimicrobial peptides (AMPs), bacteriophages and their lytic enzymes, vaccination and other emerging therapies for prevention and treatment of mastitis in dairy cows. Although many of these approaches currently lack proven therapeutic efficacy, at least some may gradually replace antibiotics, especially as drug-resistant bacteria are proliferating globally.

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Wasp Venom Peptide (Polybia MP-1) Shows Antimicrobial Activity Against Multi Drug Resistant Bacteria Isolated from Mastitic Cow Milk

Shah

Shrivastava

Gogoi

et al. 2022

Int J Pept Res Ther

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Synthetic Antimicrobial Peptide Polybia MP-1 (Mastoparan) Inhibits Growth of Antibiotic Resistant Pseudomonas aeruginosa Isolates From Mastitic Cow Milk

Cited by 5 publications

References 55 publications

Confronting the complexities of antimicrobial management for Staphylococcus aureus causing bovine mastitis: an innovative paradigm

Confronting the complexities of antimicrobial management for Staphylococcus aureus causing bovine mastitis: an innovative paradigm

Alternatives to antibiotics for treatment of mastitis in dairy cows

Wasp Venom Peptide (Polybia MP-1) Shows Antimicrobial Activity Against Multi Drug Resistant Bacteria Isolated from Mastitic Cow Milk

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