2018
DOI: 10.1016/j.bbamem.2018.06.005
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Synthetic antimicrobial peptides delocalize membrane bound proteins thereby inducing a cell envelope stress response

Abstract: These AMPs show potential for eventual clinical application against Gram-positive bacterial cells and merit further application-oriented investigation.

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Cited by 34 publications
(33 citation statements)
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“…A concentration of 7 μM TC84 prevented the growth of 1 × 10 7 vegetative cells, whereas 56 μM Alexa488-labeled TC84 was unable to completely prevent the outgrowth of 1 × 10 7 or 1 × 10 5 cells after about 13 h of treatment. Since the MBC values for TC84 against vegetative cells and spores were not significantly different ( Omardien et al, 2018a and Table 1 of the current paper), we estimate that the effect of Alexa488-labeled TC84 will be similar against vegetative cells and spores. In this study, the Alexa488-labeled TC84 should be viewed as a fluorescent probe that behaves similar but certainly not identical to the native TC84 peptide.…”
Section: Resultsmentioning
confidence: 62%
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“…A concentration of 7 μM TC84 prevented the growth of 1 × 10 7 vegetative cells, whereas 56 μM Alexa488-labeled TC84 was unable to completely prevent the outgrowth of 1 × 10 7 or 1 × 10 5 cells after about 13 h of treatment. Since the MBC values for TC84 against vegetative cells and spores were not significantly different ( Omardien et al, 2018a and Table 1 of the current paper), we estimate that the effect of Alexa488-labeled TC84 will be similar against vegetative cells and spores. In this study, the Alexa488-labeled TC84 should be viewed as a fluorescent probe that behaves similar but certainly not identical to the native TC84 peptide.…”
Section: Resultsmentioning
confidence: 62%
“…The peripheral membrane protein, MreB, delocalizes from the membrane when the membrane potential is lost after treatment with proton ionophore CCCP ( Strahl and Hamoen, 2010 ), lipopeptide daptomycin ( Müller et al, 2016 ), and synthetic cyclic hexapeptide cWFW ( Scheinpflug et al, 2017 ). Previously, we showed that TC19, TC84, and BP2 cause delocalization of essential membrane bound proteins, including MreB, due to the distortion of the membrane by the peptides ( Omardien et al, 2018a ). MreB is an important protein for lateral cell elongation during cell growth ( Carballido-López and Formstone, 2007 ).…”
Section: Resultsmentioning
confidence: 99%
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“…[ 4 ] AMPs comprise host defensive peptides, with multiple targets on pathogenic microbes and are thus effective by several routes of action. [ 3a,5 ] This diversification reduces the selective pressure that drives the evolution of bacterial resistivity. [ 6 ] AMPs also mediate pro‐ and anti‐inflammatory cascades, and induce enhanced wound healing via mechanisms other than antibacterial properties.…”
Section: Introductionmentioning
confidence: 99%
“…Extra-cytoplasmic envelope stress responses are common virulence mechanisms employed by bacterial pathogens [5][6][7] . Similarly, antibiotics, antimicrobial peptides (natural or synthetic) could trigger the cell envelope stress responses [8,9] . Some of the pathways involved in the restoration of biophysical properties could be conserved.…”
Section: Introductionmentioning
confidence: 99%