Synthetic Antioxidant Polymers: Enzyme Mimics

Wang, Cheng; Yan, Ganglin; Luo, Gaoxing

doi:10.1002/9781118445440.ch10

Cited by 1 publication

(2 citation statements)

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“…Antioxidant enzymes have been explored as alternatives, but with limited success, since they are prone to pH dependent inactivation and proteolytic cleavage. Enzyme mimics possessing catalytic activities have been designed, however the synthesis protocol often involves multiple steps [1]. While natural antioxidants are still used in many food applications, use of synthetic AO is controversial due to toxicity concerns.…”

Section: Introductionmentioning

confidence: 99%

“…Mixed results from decades of anti-oxidant research has indicated that for an antioxidant therapy to be efficient, three conditions need to be met- (1) The antioxidant must be able to scavenge the correct radicals (2) the radical scavenging must be targeted to the cells during the appropriate time (3) AO must remain active and not degrade for a significant amount of time. In this context the exploration of polymers of phenols as potent and long-lasting AO is relevant.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant Activity of Synthetic Polymers of Phenolic Compounds

Nagarajan

Kumar

et al. 2020

Polymers

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In recent years, developing potent antioxidants has been a very active area of research. In this context, phenolic compounds have been evaluated for their antioxidant activity. However, the use of phenolic compounds has also been limited by poor antioxidant activity in several in vivo studies. Polymeric phenols have received much attention owing to their potent antioxidant properties and increased stability in aqueous systems. To be truly effective in biological applications, it is important that these polymers be synthesized using benign methods. In this context, enzyme catalyzed synthesis of polymeric phenols has been explored as an environmentally friendly and safer approach. This review summarizes work in enzymatic syntheses of polymers of phenols. Several assays have been developed to determine the antioxidant potency of these polymeric phenols. These assays are discussed in detail along with structure-property relationships. A deeper understanding of factors affecting antioxidant activity would provide an opportunity for the design of versatile, high performing polymers with enhanced antioxidant activity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%