Synthetic aperture focusing technique for photoacoustic endoscopy

Cai, De; Li, Guangyao; Xia, Dongqing; Li, Zhongfei; Guo, Zhendong; Chen, Sung‐Liang

doi:10.1364/oe.25.020162

Cited by 34 publications

(21 citation statements)

References 25 publications

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“…The former is termed as optical‐resolution PAM (OR‐PAM) , and the latter acoustic‐resolution PAM (AR‐PAM) . Over the past few years, many attempts have been made to implement PAM as miniature probes, also called photoacoustic endoscopy (PAE) , which enables PAM of internal organs. PAE is desired for minimally invasive interventional procedures.…”

Section: Introductionmentioning

confidence: 99%

Miniature probe for dual‐modality photoacoustic microscopy and white‐light microscopy for image guidance: A prototype toward an endoscope

Liang

et al. 2020

Journal of Biophotonics

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In this study, a novel photoacoustic microscopy (PAM) probe integrating white‐light microscopy (WLM) modality that provides guidance for PAM imaging and complementary information is implemented. One single core of an imaging fiber bundle is employed to deliver a pulsed laser for photoacoustic excitation for PAM mode, which provides high resolution with deep penetration. Meanwhile, for WLM mode, the imaging fiber bundle is used to transmit two‐dimensional superficial images. Lateral resolution of 7.2 μm for PAM is achieved. Since miniature components are used, the probe diameter is only 1.7 mm. Imaging of phantom and animals in vivo is conducted to show the imaging capability of the probe. The probe has several advantages by introducing the WLM mode, such as being able to conveniently identify regions of interest and align the focus for PAM mode. The prototype of an endoscope shows potential to facilitate clinical photoacoustic endoscopic applications.

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Section: Introductionmentioning

confidence: 99%

Miniature probe for dual‐modality photoacoustic microscopy and white‐light microscopy for image guidance: A prototype toward an endoscope

Liang

et al. 2020

Journal of Biophotonics

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“…It benefits from the rich optical absorption contrast of tissue and offers ultrasonic resolution at an imaging depth comparable to DOT. PA imaging has several variants, such as photoacoustic tomography (PAT), with applications in small-animal imaging for preclinical research [1][2][3], mammography [4][5][6], imaging of extremities of the human body [7], endoscopy [8], and hand-held systems in combination with linear array ultrasound (US) systems [9]. In PA imaging, tissue is excited by a short (∼ns) laser pulse; as a result, the local absorption of light by tissue chromophores leads to a local pressure rise, which subsequently relaxes by the emission of broadband acoustic waves.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic and acousto-optic tomography for quantitative and functional imaging

Hussain¹,

Hondebrink²,

Staley³

et al. 2018

Optica

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Optical absorption contrast, large imaging depth at ultrasonic resolution, and the potential of functional/quantitative imaging are the features driving the rapid development of photoacoustic (PA) imaging. For quantitative and functional PA imaging, the fluence distribution is required to transform a PA image to a map of absorption coefficients. A suitable method to estimate the fluence for in vivo applications must not require a priori knowledge of the medium optical properties, should work for various illumination conditions, and must be applicable to different PA imaging geometries. Existing methods of estimating fluence in tissue do not meet these requirements simultaneously. Here we present a method to measure the fluence distribution in tissue using acousto-optics (AO) that meets all the above requirements. We developed a PA and AO tomography system for small-animal imaging to investigate the potential and the feasibility of fluence-corrected PA imaging using our method in a single instrument. We performed experiments on phantoms, an ex vivo tissue sample, and freshly sacrificed mice. We demonstrate that the correction for spatial and spectral fluence variations in PA images establishes the direct relation between image value and optical absorption, which in turns improves the quantitative estimation of blood oxygen saturation.

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“…Bandwidth up to 80 MHz has also been achieved . Photoacoustic imaging based on the fiber FP sensor has been extensively investigated . For another example, a microring resonator with NEP of 105 Pa over ultrabroad bandwidth of 350 MHz has been reported , and promising applications of microrings including PACT , OR‐PAM , PAE , ultrasound imaging and even the detection of THz pulse radiation have been demonstrated .…”

Section: Introductionmentioning

confidence: 99%

Miniature probe for all‐optical double gradient‐index lenses photoacoustic microscopy

Guo

Chen

2018

Journal of Biophotonics

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A novel all-optical double gradient-index (GRIN) lens optical-resolution photoacoustic microscopy (OR-PAM), termed as DGL-PAM, is demonstrated. The miniature probe consists of a single-mode fiber and double GRIN lenses for optical focusing and a miniature fiber Fabry-Perot sensor for ultrasound detection. The new design is simple and realizes high resolution with long working distance (WD) by virtue of the double GRIN lenses. The overall size of the probe is 2.7 mm in diameter. High lateral resolution of 3.7 μm (at 532 nm laser wavelength) and long WD of 5.5 mm are achieved. In vivo OR-PAM of mouse ear demonstrates the imaging ability of DGL-PAM. Since precise alignment of optical and acoustic foci is not needed, the proposed DGL-PAM is relatively easy to implement. It has potential to be developed as a low-cost, disposable OR-PAM probe and for endoscopic applications. The proposed double GRIN lenses for making miniature endoscopic probes can also be applied to other modalities, such as optical coherence tomography and confocal fluorescence microscopy, to enable high resolution and long WD.

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Synthetic aperture focusing technique for photoacoustic endoscopy

Cited by 34 publications

References 25 publications

Miniature probe for dual‐modality photoacoustic microscopy and white‐light microscopy for image guidance: A prototype toward an endoscope

Miniature probe for dual‐modality photoacoustic microscopy and white‐light microscopy for image guidance: A prototype toward an endoscope

Photoacoustic and acousto-optic tomography for quantitative and functional imaging

Miniature probe for all‐optical double gradient‐index lenses photoacoustic microscopy

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