Synthetic Approach for Substituted 3-Amino-1,2,4-Triazines and their Chemical Reactivity and Biological Properties

Abstract

Synthesis of substituted 1,2,4-triazines bearing an amino group and their behavior towards carbonitrile, carbonyl and isothiocyanate reagents were reviewed. The pharmacological and medicinal properties of these systems were also reported.

Synthesis and Chemistry of Phosphorus Compounds Substituted by 1,2,4-Triazine Moieties as Medicinal Probes

“…Besides, the introduction of fluorine atoms to heterocyclic nitrogen systems often enhances and improves their biological properties. [46][47][48] Based upon these observations, Makki et al 16 36). 50 Compounds 100-102 showed antioxidant activity.…”

“…32,33 Recently, 3-mercapto/amino/hydrazino-1,2,4-triazin-5-one derivatives have been gathering considerable interest in various applications in chemotherapy and biological area. [35][36][37] In addition, α-aminophosphonic acid bearing 1,2,4-triazine derivatives have high importance in the pharmacological and biological fields, 38,39 such as HIV inhibitors, 40 protease antagonists, 41 collagenase inhibitors, 42 anticancer, 43 antibacterial, 44 and antiviral, 45 probes. Besides, the introduction of fluorine atoms to heterocyclic nitrogen systems often enhances and improves their biological properties.…”