Synthetic approaches towards 2-iminothiazolidines: an overview

D’hooghe, Matthias; Kimpe, Norbert De

doi:10.1016/j.tet.2005.09.028

Cited by 118 publications

(47 citation statements)

References 85 publications

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“…Thus, styrene imine derivative 11 engages in [3 þ 2] cycloaddition with acetonitrile in the presence of boron trifluoride etherate at room temperature to give the corresponding imidazoline (152) us [217] can be derived from aziridines at room temperature using a palladium(II) acetate/triphenylphosphine catalyst system. Thus, phenylisothiocyanate is inserted into the CÀN bond of vinylaziridine 153 to give the ring-expanded product 154 in excellent yield [218].…”

Section: Ring Expansionsmentioning

confidence: 99%

Three‐Membered Heterocycles. Structure and Reactivity

Murphree

2011

Modern Heterocyclic Chemistry

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Section: Ring Expansionsmentioning

confidence: 99%

Three‐Membered Heterocycles. Structure and Reactivity

Murphree

2011

Modern Heterocyclic Chemistry

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“…Complexation has immense potential to augment the bioactivities of organic compounds (D'hooghe and De Kimpe 2006;Cao et al 2005), which are influenced by the metal ions, the ligands and the structure of the complex (Katari and Srinivas 2014). Biologically relevant metal complexes have several other requirements in terms of their synthetic design, viz, their high thermodynamic stability to deliver the metal to the active site, their hydrolytic stability by which metal ion undergoes ligation or de-ligation reactions (Shoaib et al 2013), their molecular weight which helps them to reach the proper target site in the body.…”

Section: Introductionmentioning

confidence: 99%

Sonochemical synthesis of novel magnesium 1,2,4-triazole-1-carbodithioate nanoparticles as antifungals

2017

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Novel magnesium 1,2,4-triazole-1-carbodithioates were sonochemically synthesized as water-dispersable nanoparticles owing to their water insolubility. The two-step reaction protocol was followed to synthesize the novel triazole ligand system for complexation with magnesium metal due to its low biological toxicity. Different concentrations of Poly Vinyl Pyrrolidine were used to stabilize and standardise the size of nanoparticles, which were characterised by TEM analysis. UV-Visible and infrared spectroscopies were used to analyse the metal ligand interaction, and CHNS analysis was used to propose the structure of the metal complex. The spore germination inhibition technique was used to evaluate the antifungal potential of synthesized nano-complexes against two phytopathogenic test fungi viz. A. alternata and F. moniliforme. The nanoparticles had inflicted moderate in vitro inhibition of fungal growth, which was comparable to standard fungicide Indofil M-45. The in silico toxicity of the compounds was made using the Toxtree analysis software that indicated the compounds belong to class III group of toxicity, which was same as that of commercial standards of DTC.

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“…Thiourea derivatives are valuable synthetic intermediates and are widely used in the synthesis of biologically active compounds [1]. Thioureas demonstrated a broad spectrum of biological activities such as anti-HIV [2], antiviral [3], vanilloid receptor antagonism [4], antibacterial [5], antifungal [6][7][8], anticancer [9], and anti-allergic [10] activities.…”

Section: Introductionmentioning

confidence: 99%