Synthetic biodegradable medical polyurethanes

Chiono, Valeria; Sartori, Susanna; Calzone, Stefano; Boffito, Monica; Tonda‐Turo, Chiara; Mattu, Clara; Gentile, Piergiorgio; Ciardelli, Gianluca

doi:10.1016/b978-0-08-100372-5.00006-4

Cited by 13 publications

(10 citation statements)

References 99 publications

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“…The ability of the enzyme to adsorb onto the surface in a conformational state that will permit cleavage of the polymer is important in determining the relation between biomaterial chemistry and the stability of the material in the biological environment [539]. The stability of PU elastomers against enzymatic hydrolysis has been found to depend on the hydrophilicity of the SS component [505,540]. In particular, a PU with hydrophilic PEG segments was more susceptible to enzymatic hydrolysis (in papain solution) than PTMEG-and PB-based PUs [518].…”

Section: General Discussion On Enzymatic Degradation Of Polyurethane mentioning

confidence: 99%

Degradation and stabilization of polyurethane elastomers

Xie

Zhang

Bryant

et al. 2019

Progress in Polymer Science

453

301

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Section: General Discussion On Enzymatic Degradation Of Polyurethane mentioning

confidence: 99%

Degradation and stabilization of polyurethane elastomers

Xie

Zhang

Bryant

et al. 2019

Progress in Polymer Science

453

301

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“…The advancement in biomaterials science, including the design and development of new synthetic copolymers, ceramic and glass–ceramics, bioartificial blends of natural and synthetic materials, can be exploited to finely tune the chemical, thermal, mechanical and surface properties of the scaffold-forming materials (Baino and Vitale-Brovarone, 2011 ; Sionkowska, 2011 ; Sartori et al, 2013 ; Boffito et al, 2014 , 2015 ; Silvestri et al, 2014 ; Baino et al, 2015 ; Chiono et al, 2016 ). The progress of these custom-made materials allows to accurately recapitulate the bulk properties of the native tissue at different health levels.…”

Section: Discussion and Future Directionsmentioning

confidence: 99%

Tissue Engineering Approaches in the Design of Healthy and Pathological In Vitro Tissue Models

Caddeo

Boffito

Sartori

2017

Front. Bioeng. Biotechnol.

221

172

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In the tissue engineering (TE) paradigm, engineering and life sciences tools are combined to develop bioartificial substitutes for organs and tissues, which can in turn be applied in regenerative medicine, pharmaceutical, diagnostic, and basic research to elucidate fundamental aspects of cell functions in vivo or to identify mechanisms involved in aging processes and disease onset and progression. The complex three-dimensional (3D) microenvironment in which cells are organized in vivo allows the interaction between different cell types and between cells and the extracellular matrix, the composition of which varies as a function of the tissue, the degree of maturation, and health conditions. In this context, 3D in vitro models can more realistically reproduce a tissue or organ than two-dimensional (2D) models. Moreover, they can overcome the limitations of animal models and reduce the need for in vivo tests, according to the “3Rs” guiding principles for a more ethical research. The design of 3D engineered tissue models is currently in its development stage, showing high potential in overcoming the limitations of already available models. However, many issues are still opened, concerning the identification of the optimal scaffold-forming materials, cell source and biofabrication technology, and the best cell culture conditions (biochemical and physical cues) to finely replicate the native tissue and the surrounding environment. In the near future, 3D tissue-engineered models are expected to become useful tools in the preliminary testing and screening of drugs and therapies and in the investigation of the molecular mechanisms underpinning disease onset and progression. In this review, the application of TE principles to the design of in vitro 3D models will be surveyed, with a focus on the strengths and weaknesses of this emerging approach. In addition, a brief overview on the development of in vitro models of healthy and pathological bone, heart, pancreas, and liver will be presented.

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“…These urethane and urea groups are formed via the chemical reaction between an isocyanate group and a hydroxyl or amine group. 70 There are different classes of PUs based on their characteristics. They can be flexible, sealants, rigid, etc.…”

Section: Types Of Bioelastomers and Their Synthetic Pathwaysmentioning

confidence: 99%