Synthetic biology—change, accelerated

Venton, Danielle

doi:10.1073/pnas.1419688111

Cited by 3 publications

(3 citation statements)

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“…Artemisinin, extracted from Artemisia annua and a precursor to the anti-malarial drug artesunate, is very expensive and laborious to isolate. With the arrival of synthetic technology, the metabolic pathway required for the production of artemisinin has been successfully introduced into yeast, and a synthetic life form capable of producing artemisinin has been created (Venton, 2014); the prices associated with the drug have also dropped substantially. In the modern day, large-scale production of artemisinin is both feasible and happening because of synthetic technology; current production is by the ton with an expected yield of 50-60 tons per year in 2014 (Sanders).…”

Section: Target Compound Productionmentioning

confidence: 99%

“…Further, synthetic life forms can be designed to withstand harsh conditions, to produce target compounds, or to detect and convert substances present in soil among many other functions (Ferry et al, 2012). Yet another application could be in the removal of carbon dioxide and production of biofuels by synthetic life forms (designed to consume carbon dioxide) (Venton, 2014). Synthetic life forms are also candidates for biofuel production.…”

Section: Target Compound Productionmentioning

confidence: 99%

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Artificial life forms: the strains of the future?

Rajalingham

2015

bta

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Synthetic biology is the field of biology that is involved in the manufacturing of genomic material designed by man with subsequent introduction into a chassis. A synthetic life has a minimal genome of about 500-800 genes as well as a few additional genes required to fulfill a particular task. Synthetic life forms can be used for the production of valuable target compounds such as the antimalarial drug artemisinin. This technology is applicable to all subfields of biotechnology and biology, but it is, in particular, relevant for the making of target compounds; it can be used for the making of biofuels, drugs, energy, artificial photosynthesis, in medicine, bioremediation/biosensors, in the chemical industry, and in agriculture. It is believed that these novel artificial strains will become the ruling strains in the near future with many a use in many a field. This paper outlines the positive aspects of synthetic life forms as well as the methods used to generate artificial life forms.

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Section: Target Compound Productionmentioning

confidence: 99%

Section: Target Compound Productionmentioning

confidence: 99%

Artificial life forms: the strains of the future?

Rajalingham

2015

bta

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“…"Malaria would have to either find another host or go extinct," says Esvelt. The tactic requires a genetic element called a "gene drive," which selfishly promotes its own inheritance, for example by copying itself onto other chromosomes (11). Although the gene drive idea has been around for decades, and scientists have shown the basic principle could work in insects, CRISPR will likely perform much better than previous gene-editing methods, Esvelt and Church predict (12)(13)(14)(15)(16).…”

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confidence: 99%