Synthetic Biology in Cell and Organ Transplantation

Stevens, Sean

doi:10.1101/cshperspect.a029561

Cited by 3 publications

(2 citation statements)

References 61 publications

(56 reference statements)

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“…Alternatively, if no close relatives are available, haplotype matching could be considered [ 170 ]. Another ethically tricky option for allotransfer is the potential to use the still-viable mitochondria from a dead human relative in treatment [ 171 , 172 ]. The final donor source option, xenotransfer, involves the transfer of mitochondria from another species to humans [ 173 ].…”

Section: Ethical Issuesmentioning

confidence: 99%

Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications

Caicedo

Aponte

Cabrera

et al. 2017

Stem Cells International

114

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The objective of this review is to outline existing artificial mitochondria transfer techniques and to describe the future steps necessary to develop new therapeutic applications in medicine. Inspired by the symbiotic origin of mitochondria and by the cell's capacity to transfer these organelles to damaged neighbors, many researchers have developed procedures to artificially transfer mitochondria from one cell to another. The techniques currently in use today range from simple coincubations of isolated mitochondria and recipient cells to the use of physical approaches to induce integration. These methods mimic natural mitochondria transfer. In order to use mitochondrial transfer in medicine, we must answer key questions about how to replicate aspects of natural transport processes to improve current artificial transfer methods. Another priority is to determine the optimum quantity and cell/tissue source of the mitochondria in order to induce cell reprogramming or tissue repair, in both in vitro and in vivo applications. Additionally, it is important that the field explores how artificial mitochondria transfer techniques can be used to treat different diseases and how to navigate the ethical issues in such procedures. Without a doubt, mitochondria are more than mere cell power plants, as we continue to discover their potential to be used in medicine.

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Section: Ethical Issuesmentioning

confidence: 99%

Artificial Mitochondria Transfer: Current Challenges, Advances, and Future Applications

Caicedo

Aponte

Cabrera

et al. 2017

Stem Cells International

114

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show abstract

“…Alternatively, if no close relatives are available, haplotype matching could be considered [ 132 ]. Another ethically tricky option for all transfers is the potential use of still-viable mitochondria from a dead human relative in treatment [ 133 , 134 ].…”

Section: Problems In Mitochondrial Transfermentioning

confidence: 99%

Mitochondrial transplantation: opportunities and challenges in the treatment of obesity, diabetes, and nonalcoholic fatty liver disease

et al. 2022

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Metabolic diseases, including obesity, diabetes, and nonalcoholic fatty liver disease (NAFLD), are rising in both incidence and prevalence and remain a major global health and socioeconomic burden in the twenty-first century. Despite an increasing understanding of these diseases, the lack of effective treatments remains an ongoing challenge. Mitochondria are key players in intracellular energy production, calcium homeostasis, signaling, and apoptosis. Emerging evidence shows that mitochondrial dysfunction participates in the pathogeneses of metabolic diseases. Exogenous supplementation with healthy mitochondria is emerging as a promising therapeutic approach to treating these diseases. This article reviews recent advances in the use of mitochondrial transplantation therapy (MRT) in such treatment.

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