Synthetic biopolymer nanocomposites for tissue engineering scaffolds

Okamoto, Masami; John, Baiju

doi:10.1016/j.progpolymsci.2013.06.001

Cited by 454 publications

(258 citation statements)

References 118 publications

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“…Scaffolds derived from synthetic polymeric materials may offer advantages over natural biomaterials, such as reproducibility; their well-defined chemical composition can allow for precise control over mechanical properties and degradation rates (Okamoto and John 2013). However, synthetic biomaterials suffer from a major disadvantage as they often lack sites for cell adhesion; therefore, many need to be modified to introduce cell attachment cues, such as matrix ligands, for adhesion (O'Brien 2011).…”

Section: Introductionmentioning

confidence: 99%

Surface modified cellulose scaffolds for tissue engineering

et al. 2016

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We report the ability of cellulose to support cells without the use of matrix ligands on the surface of the material, thus creating a two-component system for tissue engineering of cells and materials. Sheets of bacterial cellulose, grown from a culture medium containing Acetobacter organism were chemically modified with glycidyltrimethylammonium chloride or by oxidation with sodium hypochlorite in the presence of sodium bromide and 2,2,6,6-tetramethylpipiridine 1-oxyl radical to introduce a positive, or negative, charge, respectively. This modification process did not degrade the mechanical properties of the bulk material, but grafting of a positively charged moiety to the cellulose surface (cationic cellulose) increased cell attachment by 70% compared to unmodified cellulose, while negatively charged, oxidised cellulose films (anionic cellulose), showed low levels of cell attachment comparable to those seen for unmodified cellulose. Only a minimal level of cationic surface derivitisation (ca 3% degree of substitution) was required for increased cell attachment and no mediating proteins were required. Cell adhesion studies exhibited the same trends as the attachment studies, while the mean cell area and aspect ratio was highest on the cationic surfaces. Overall, we demonstrated the utility of positively charged bacterial cellulose in tissue engineering in the absence of proteins for cell attachment.

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Section: Introductionmentioning

confidence: 99%

Surface modified cellulose scaffolds for tissue engineering

et al. 2016

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“…Tissue engineering has emerged as a revolutionary approach with an enormous impact on clinical applied sciences and is considered to have a huge potential in the market [16].…”

Section: Nanocomposites In Tissue Engineeringmentioning

confidence: 99%

“…Current nanostructures employed to build bionanocomposites comprise three main groups [16] ( Figure 1). …”

Section: Nanofillersmentioning

confidence: 99%

Nanocomposites for Additive Manufacturing

Redón¹,

Ruiz‐Huerta²,

Almanza-Arjona³

et al. 2017

AJCR

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“…Electrospinning generates porous mats with high porosity and high surface area which can mimic extracellular matrix structure (ECM) and therefore makes itself a good candidate for use in tissue engineering [5,6]. In this sense, biodegradable and bio absorbable polymers like saturated poly (α-hydroxyl) esters have been currently used [7]. A biodegradable polyester that has already demonstrated good biological safety and displayed almost no cytotoxicity is the PBAT [8].…”

Section: Introductionmentioning

confidence: 99%

Composites structures for bone tissue reconstruction

Neto

Santos

Avérous

et al. 2015

AIP Conference Proceedings

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Abstract. The search for new biomaterials in the bone reconstitution field is growing continuously as humane life expectation and bone fractures increase. For this purpose, composite materials with biodegradable polymers and hydroxyapatite (HA) have been used. A composite material formed by a film, nanofibers and HA has been made. Both, the films and the non-woven mats of nanofibers were formed by nanocomposites made of butylene adipate-co-terephthalate (PBAT) and HA. The techniques used to produce the films and nanofibers were spin coating and electrospinning, respectively. The composite production and morphology were evaluated. The composite showed an adequate morphology and fibers size to be used as scaffold for cell growth.

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Synthetic biopolymer nanocomposites for tissue engineering scaffolds

Cited by 454 publications

References 118 publications

Surface modified cellulose scaffolds for tissue engineering

Surface modified cellulose scaffolds for tissue engineering

Nanocomposites for Additive Manufacturing

Composites structures for bone tissue reconstruction

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