Synthetic blood anticoagulants based on polyacrolein

New atranes and similar ionic complexes. Synthesis, structure, properties

“…Functionalization of silatranes with different groups in exocyclic position is an important trend as the resulting compounds retain the activities of silatranes as well as substituted groups. [13,18,[21][22][23][24][29][30][31][32][33][34][35][36][37]66,67] To obtain new potentially bioactive silatranes 5, we have carried out the reaction of 3-amino-propylsilatrane with acetic and bioactive (het)arylchalcogenylacetic acids under mild conditions. Unlike 1-alkylsilatranes (Scheme 3), the reaction proceeds with preservation of the silatranic skeleton (Scheme 5).…”

“…3-Aminopropylsilatrane represents a convenient building block for design of numerous new advanced materials and pharmacologically active compounds. [29][30][31][32][33][34][35][36][37] On the other hand, aldehydes are known to react with primary amines to deliver imines which can also be employed as precursors of drugs including antitumor ones. [68,69] The data on reactions of 3-aminopropylsilane with unsaturated aldehydes are scant.…”

“…Due to their unusual architecture (the N → Si bond, the pentacoordinated silicon atom, the tricyclic structure), high dipole moment and strong electrondonating effect of the silatrane skeleton, silatranes are of interest not only as theoretical objects [13][14][15][16][17] but also as important functional reagents, [18][19][20][21][22][23][24] advanced materials (Si-organic polyimide films, [25] catalysts, [26] optical probes, [27] adhesion layers for nanoparticles [28] ), as well as physiologically and pharmacologically active compounds. [29][30][31][32][33][34][35][36][37] Some atranes have already found application in agriculture and medicine as growth-regulating agents, veterinary drugs and pharmaceuticals. These are 1-chloromethyl-, 1-ethoxysilatranes (Mival and Migugene) and triethanolammonium salt of biologically active 2-methylphenyloxyacetic acid (protatranes Crezacine or Trekrezane) [N (CН 2 СН 2 ОН) 3 Н] + .…”