2014
DOI: 10.1016/j.mayocp.2014.06.013
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Synthetic Cannabinoid Leading to Cannabinoid Hyperemesis Syndrome

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Cited by 28 publications
(13 citation statements)
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“…The best evidence suggests a dynamic interplay between cannabinoid metabolism and complex pharmacodynamics at the CB-1 receptor. In addition, our study identified three unique cases of CHS caused by synthetic cannabinoids [23,41,182]. These agents are potent agonists of the cannabinoid CB1 receptors, similar to THC, suggesting that agonism at the CB1 receptor may be responsible for CHS.…”
Section: Discussionmentioning
confidence: 76%
“…The best evidence suggests a dynamic interplay between cannabinoid metabolism and complex pharmacodynamics at the CB-1 receptor. In addition, our study identified three unique cases of CHS caused by synthetic cannabinoids [23,41,182]. These agents are potent agonists of the cannabinoid CB1 receptors, similar to THC, suggesting that agonism at the CB1 receptor may be responsible for CHS.…”
Section: Discussionmentioning
confidence: 76%
“…9 CHS can also be caused by use of ''Spice,'' a group of designer drugs that contain synthetic cannabinoids, such as the potent 1-pentyl-3-(1-naphthoyl)indole ( JWH-018). [10][11][12][13][14][15] Unlike THC, JWH-018 acts as a full agonist of CB 1 . [10][11][12][13][14][15] Spice is associated with more severe side effects, including anxiety, panic, delusions, and hallucinations, as well as nausea and vomiting.…”
Section: Introductionmentioning
confidence: 99%
“…[10][11][12][13][14][15] Unlike THC, JWH-018 acts as a full agonist of CB 1 . [10][11][12][13][14][15] Spice is associated with more severe side effects, including anxiety, panic, delusions, and hallucinations, as well as nausea and vomiting. [10][11][12][16][17][18][19][20] Individuals who use Spice are more likely than cannabis users to seek emergency room treatments because of its more adverse side effects, 21 including nausea and vomiting.…”
Section: Introductionmentioning
confidence: 99%
“…Yoo, Liu, and Villamagna for reading our recently published article and appreciate their insights regarding the difficult nature of diagnosing cannabinoid hyperemesis syndrome (CHS) in patients using synthetic cannabinoids and the potentially large health burden of this illness.Our systematic review identified the three referenced case reports of CHS [1][2][3] secondary to synthetic cannabinoid use and we included them in our synthesis. Although the clinical toxidromes associated with synthetic cannabinoids can differ from those of natural cannabinoids, synthetic cannabinoids interact with the CB1 receptor [4] and since these cases meet our criteria for CHS diagnosis [5], we believe that these cases should be labeled as CHS and treated as such.…”
mentioning
confidence: 99%
“…Our systematic review identified the three referenced case reports of CHS [1][2][3] secondary to synthetic cannabinoid use and we included them in our synthesis. Although the clinical toxidromes associated with synthetic cannabinoids can differ from those of natural cannabinoids, synthetic cannabinoids interact with the CB1 receptor [4] and since these cases meet our criteria for CHS diagnosis [5], we believe that these cases should be labeled as CHS and treated as such.…”
mentioning
confidence: 99%