Synthetic CDCA Derivatives-Induced Apoptosis of Stomach Cancer Cell Line SNU-1 Cells

Moon, Bongkyung; Kim, Min-Chan; Park, Joo-Sung

doi:10.4143/crt.2004.36.2.132

Cited by 7 publications

(6 citation statements)

References 25 publications

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“…More and more evidences have indicated that CDCA (cell division cycle associated protein) is important in tumor evolution [ 5 , 6 ]. CDCA4 has been reported to be a potential biomarker for clinical outcome of osteosarcoma patients [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

The Higher Expression of CDCA2 Associated with Poor Prognosis in Glioma

Jin

Sun

Zhou³

et al. 2022

Disease Markers

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Glioma is the most common primary intracranial tumor and is related to poor clinical outcomes. The developments of sensitive markers can be applied to reveal the mechanisms involved in the progression of glioma. This study examined CDCA2 expression in glioma samples and its significance in predicting glioma patient outcome. GEPIA and GEO datasets were used to explore the expression of CDCA2 in glioma. Kaplan-Meier and multivariate assays were applied to delve into the prognostic values of CDCA2 expression in glioma patients using CGGA datasets. Our group also determined the associations between CDCA2 and clinical characteristics. Coexpression analysis was performed. In this research, we observed that CDCA2 expression was distinctly upregulated in glioma specimens compared with nontumor specimens. The prognosis of glioma with high CDCA2 expression was distinctly worse compared with that of glioma with low CDCA2 expression. Additionally, multivariate Cox regression analysis revealed that high CDCA2 expression was an independent poor prognostic indicator for glioma patients. High expression of CDCA2 was positively associated with advanced clinical progression. Coexpression analysis revealed that CDCA2 could be positively related to ASPM, SKA1, DLGAP5, NCAPG, and CDCA8 and was negatively associated with ETNPPL, LDHD, MRVI1, CBX7, and CENPJ. Overall, our findings revealed that CDCA2 might serve as an independent prognosis indicator for glioma.

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Section: Introductionmentioning

confidence: 99%

The Higher Expression of CDCA2 Associated with Poor Prognosis in Glioma

Jin

Sun

Zhou³

et al. 2022

Disease Markers

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“…These agents have anti-tumor activity in gastric cancer, HCC, breast cancer, cervical cancer, prostate cancer, and T-cell leukemia. 99–104 …”

Section: Therapeutic Roles Of Bile Acid and Bile Acid Modulationmentioning

confidence: 99%

Functional, Diagnostic and Therapeutic Aspects of Bile

Ahmed¹

2022

CEG

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Bile is a unique body fluid synthesized in our liver. Enterohepatic circulation preserves bile in our body through its efficient synthesis, transport, absorption, and reuptake. Bile is the main excretory route for bile salts, bilirubin, and potentially harmful exogenous lipophilic substances. The primary way of eliminating cholesterol is bile. Although bile has many organic and inorganic contents, bile acid is the most physiologically active component. Bile acids have a multitude of critical physiologic functions in our body. These include emulsification of dietary fat, absorption of fat and fat-soluble vitamins, maintaining glucose, lipid, and energy homeostasis, sustenance of intestinal epithelial integrity and epithelial cell proliferation, reducing inflammation in the intestine, and prevention of enteric infection due to its antimicrobial properties. But bile acids can be harmful in certain altered conditions like cholecystectomy, terminal ileal disease or resection, cholestasis, duodenogastric bile reflux, duodenogastroesophageal bile reflux, and bile acid diarrhea. Bile acids can have malignant potentials as well. There are also important diagnostic and therapeutic roles of bile acid and bile acid modulation.

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“…First, many researchers have shown that the UDCA derivatives HS-1030 and HS-1183, and the CDCA derivatives HS-1199 and HS-1200 induced apoptosis in various human cancer cells [22,[161][162][163][164][165][166][167][168][169][170][171]. HS-1030 is a form of UDCA conjugated with glycine methyl esters (Figure 3A,B).…”

Section: Cell Death Mechanism Of Synthetic Bile Acid Derivatives In C...mentioning

confidence: 99%

“…Treatment with synthetic bile acid derivatives (HS-1183, HS-1199, and HS-1200) reduced the levels of pro-caspase-3 and caspase-8 in Jurkat human leukemic T cells [161]. In addition, the levels of pro-caspase-3 were reduced in SNU-1 stomach cancer cells [165,166] and malignant glioblastoma cells (U-118MG, U-87MG, T98G, and U-373MG) [167]. Furthermore, HS-1200 decreased the levels of pro-caspase-3 and procaspase-7 in KAT-18 thyroid carcinoma cells [171].…”

Section: Cell Death Mechanism Of Synthetic Bile Acid Derivatives In C...mentioning

confidence: 99%

Mechanism of Bile Acid-Induced Programmed Cell Death and Drug Discovery against Cancer: A Review

Jang

Choi

Kim

2022

IJMS

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Bile acids are major signaling molecules that play a significant role as emulsifiers in the digestion and absorption of dietary lipids. Bile acids are amphiphilic molecules produced by the reaction of enzymes with cholesterol as a substrate, and they are the primary metabolites of cholesterol in the body. Bile acids were initially considered as tumor promoters, but many studies have deemed them to be tumor suppressors. The tumor-suppressive effect of bile acids is associated with programmed cell death. Moreover, based on this fact, several synthetic bile acid derivatives have also been used to induce programmed cell death in several types of human cancers. This review comprehensively summarizes the literature related to bile acid-induced programmed cell death, such as apoptosis, autophagy, and necroptosis, and the status of drug development using synthetic bile acid derivatives against human cancers. We hope that this review will provide a reference for the future research and development of drugs against cancer.

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Synthetic CDCA Derivatives-Induced Apoptosis of Stomach Cancer Cell Line SNU-1 Cells

Abstract: Purpose: This study was conducted to explore whether C D C A derivatives induce apoptosis in a stomach cancer cell line, and to dissect the detailed mechanism underlying apoptosis.

Cited by 7 publications

References 25 publications

The Higher Expression of CDCA2 Associated with Poor Prognosis in Glioma

The Higher Expression of CDCA2 Associated with Poor Prognosis in Glioma

Functional, Diagnostic and Therapeutic Aspects of Bile

Mechanism of Bile Acid-Induced Programmed Cell Death and Drug Discovery against Cancer: A Review

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