2018
DOI: 10.1021/acsnano.8b05373
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Synthetic Charge-Invertible Polymer for Rapid and Complete Implantation of Layer-by-Layer Microneedle Drug Films for Enhanced Transdermal Vaccination

Abstract: The utility of layer-by-layer (LbL) coated microneedle (MN) skin patches for transdermal drug delivery has been proven a promising approach, with advantages over hypodermal injection due to painless and easy self-administration. However, the long epidermal application time required for drug implantation by existing LbL MN strategies (15 to 90 minutes) can lead to potential medication noncompliance. Here, we developed a MN platform to shorten the application time in MN therapies based on a synthetic pH-induced … Show more

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Cited by 79 publications
(60 citation statements)
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“…Furthermore, the magnetization‐induced self‐assembling method also can be employed to mass production of the rigid MA using different CMRF, which is potentially applied in various fields, such as transdermal vaccination, transdermal drug delivery, bio‐signals recording, bio‐sensing, superhydrophobic interface, and fog collection …”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, the magnetization‐induced self‐assembling method also can be employed to mass production of the rigid MA using different CMRF, which is potentially applied in various fields, such as transdermal vaccination, transdermal drug delivery, bio‐signals recording, bio‐sensing, superhydrophobic interface, and fog collection …”
Section: Discussionmentioning
confidence: 99%
“…Polymer MNs have also been used recently for vaccine delivery. A MN patch layer-by-layer coated with a synthetic pH-induced charge-invertible polymer was successfully used for a rapid release of an antigen and induction of an elevated immune response ( He Y. et al, 2018 ). Enhanced cancer immunization was achieved by dissolving MNs based on an amphiphilic triblock copolymer, which generated nanomicelles containing a model antigen (OVA) and a vaccine adjuvant (R848) upon insertion in the skin and dissolution ( Kim et al, 2018 ).…”
Section: Transdermal Drug Deliverymentioning
confidence: 99%
“…For instance, melanin‐modified needle patches could stimulate antitumor immunity by heating under near‐infrared light irradiation . A charge‐invertible polymer‐decorated patch could quickly insert into the skin to sustain antigen release over several days . In addition, microneedle arrays have been used to proliferate tumor‐specific T cells in vivo …”
Section: Materials For Improving Cancer Immunotherapy Outcomesmentioning
confidence: 99%