“…This is manifest in neurological symptoms and some related diseases, such as Parkinson’s disease, based on direct or exposure to these chemicals ( Hertzman et al, 1994 ; Kamel et al, 2005 ; Keifer and Firestone, 2007 ). Over the years, insects have managed to adapt to different classes insecticides resulted in developing resistance ( Heisey and Norton, 2007 ; Bass et al, 2014 ; Khan and Ahmad, 2019 ; Mohammed et al, 2019 ; Attia et al, 2020 ; Khan et al, 2020 ). For instance, the intensive use of transgenic corn with the insecticidal protein Cry1F has provoked resistance in some major corn pests, the codling moth Spodoptera frugiperda , affecting the economy and agriculture of Puerto Rico, Brazil and the United States ( Storer et al, 2010 ; Storer et al, 2012 ; Farias et al, 2014 ; Huang et al, 2014 ; Yang et al, 2016 ).…”