Synthetic Crosslinker Based on Amino–yne Click to Enhance the Suture Tension of Collagen-Based Corneal Repair Materials

Li, Haochen; Sun, Xiaomin; Huang, Yongrui; Peng, Yuehai; Liu, Jia; Li, Ren

doi:10.1021/acsapm.2c00472

Cited by 11 publications

(11 citation statements)

References 55 publications

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“…Human umbilical vein endothelial cells (EA. Hy926), mouse embryonic fibroblast cells (3T3), and mouse-derived fibroblast cells (L929) were employed to investigate the cytotoxicity of all threads through the CCK-8 assay . Each specimen was tested at least three times, and the cell viabilities were calculated based on the formula . normalc ell viability 0.25em ( % ) = normalO D sample − normalO D blank normalO D control − normalO D blank × 100 % where OD sample is the optical density (OD) of the sample and OD blank and OD control are the OD of the blank and control samples, respectively.…”

Section: Methodsmentioning

confidence: 99%

“…Hy926), mouse embryonic fibroblast cells (3T3), and mouse-derived fibroblast cells (L929) were employed to investigate the cytotoxicity of all threads through the CCK-8 assay. 4 Each specimen was tested at least three times, and the cell viabilities were calculated based on the formula 2.…”

Section: ■ Conclusionmentioning

confidence: 99%

“…Surgical threads as special medical materials have been used for wound closure since ancient times, which are of vital importance for tissue healing and prevention of infection . An ideal surgical thread should have both good basic physical properties ( e.g ., high strength, flexibility, suitable diameter, and swelling ratio) and good biological properties (such as antibacterial activity, cytocompatibility, anti-inflammation, and the promotion of rehabilitation). , According to the material category, surgical threads include silk, collagen or cellulose threads, nylon, polypropylene, polyester, polydioxanone, polyglycolic acid, − etc . Among them, Vicryl absorbable thread (polyglactin 910) and silk thread are widely used for wound closures of animals and humans due to their relatively low cost, superior mechanical strength, and ease of handling.…”

Section: Introductionmentioning

confidence: 99%

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Bioinspired, Robust, and Absorbable Cellulose Nanofibrils/Chitosan Filament with Remarkable Cytocompatibility and Wound Healing Properties

Wu,

Zhang,

et al. 2023

ACS Appl. Mater. Interfaces

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Surgical threads are of great importance to prevent wound infection and accelerate tissue healing in surgical treatment. Cellulose nanofibrils (CNF) and chitosan (CS) are attracting increasing attention to be employed as biomedicine materials due to their nontoxicity, cytocompatibility, and biodegradability. However, a robust and absorbable cellulose-based surgical thread has not been explored. Therefore, in this work, a bioinspired CNF/ CS composite thread containing 5% cationic polyacrylamide (CPAM) by the mass of CS was prepared, and the obtained CNF/CS-5C thread exhibited excellent mechanical properties and low swelling ratio in water due to the high cross-link degree. Especially, the tensile strength (1877 ± 107 MPa) of this thread was much higher than that of most reported CNF-based threads. Meanwhile, compared with commercial silk and Vicryl surgical threads, the CNF/CS-5C thread exhibited better in vitro cytocompatibility toward endothelial and fibroblast cells and lower inflammatory response in vivo to subcutaneous tissues of rats. In addition, the obtained thread could be regarded as a promising absorbable suture, which exhibited excellent wound healing performances in vivo. Therefore, the prepared absorbable thread will open a new window to prepare novel and advanced cellulosebased threads for medical applications.

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Section: Methodsmentioning

confidence: 99%

Section: ■ Conclusionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bioinspired, Robust, and Absorbable Cellulose Nanofibrils/Chitosan Filament with Remarkable Cytocompatibility and Wound Healing Properties

Wu,

Zhang,

et al. 2023

ACS Appl. Mater. Interfaces

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“…Likewise, Dove and co-workers reported several examples of hydrogels obtained using the nucleophilic thiol-yne “ click ” reaction. − In one of their studies, they demonstrated that this reaction is highly efficient for the fabrication of robust high-water-content hydrogels with tunable mechanical properties (Figure b) . Another interesting variation employs the amino-yne “ click ” reaction for obtaining cross-linked materials. − This reaction is of high interest, since several natural biopolymers possess amine groups. Huang and Jiang reported the fabrication of injectable and degradable pH-responsive carboxymethyl chitosan (CMC) hydrogels via amino-yne “ click ” reaction .…”

Section: Other “Click”-reaction-based Hydrogels and Their Applicationsmentioning

confidence: 99%

“…They used telechelic electron-deficient dipropiolate ester of polyethylene glycol and water-soluble CMC to obtain injectable and degradable hydrogels, which were nontoxic and possessed good tissue biocompatibility (Figure c). The reaction was also employed by Ren and co-workers to obtain collagen-based corneal repair membranes . Langer and co-workers used this approach with synthetic polymers to obtain fast gelation in aqueous media using a multivalent secondary amine group containing small molecule cross-linkers and tetra-PEG alkynoates.…”

Section: Other “Click”-reaction-based Hydrogels and Their Applicationsmentioning

confidence: 99%

Metal-Free Click-Chemistry: A Powerful Tool for Fabricating Hydrogels for Biomedical Applications

Degirmenci,

Sanyal,

Sanyal

2024

Bioconjugate Chem.

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Increasing interest in the utilization of hydrogels in various areas of biomedical sciences ranging from biosensing and drug delivery to tissue engineering has necessitated the synthesis of these materials using efficient and benign chemical transformations. In this regard, the advent of "click" chemistry revolutionized the design of hydrogels and a range of efficient reactions was utilized to obtain hydrogels with increased control over their physicochemical properties. The ability to apply the "click" chemistry paradigm to both synthetic and natural polymers as hydrogel precursors further expanded the utility of this chemistry in network formation. In particular, the ability to integrate clickable handles at predetermined locations in polymeric components enables the formation of welldefined networks. Although, in the early years of "click" chemistry, the copper-catalyzed azide-alkyne cycloaddition was widely employed, recent years have focused on the use of metal-free "click" transformations, since residual metal impurities may interfere with or compromise the biological function of such materials. Furthermore, many of the non-metalcatalyzed "click" transformations enable the fabrication of injectable hydrogels, as well as the fabrication of microstructured gels using spatial and temporal control. This review article summarizes the recent advances in the fabrication of hydrogels using various metalfree "click" reactions and highlights the applications of thus obtained materials. One could envision that the use of these versatile metal-free "click" reactions would continue to revolutionize the design of functional hydrogels geared to address unmet needs in biomedical sciences.

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Hydrophilic, Porous, Fiber‐Reinforced Collagen‐Based Membrane for Corneal Repair

Li,

Liu,

et al. 2024

Macromolecular Bioscience

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Collagen membrane with outstanding biocompatibility exhibits immense potential in the field of corneal repair and reconstruction, but the poor mechanical properties limit its clinical application. Polycaprolactone (PCL) is a biodegradable polymer that has been widely explored for application in corneal reconstruction due to its excellent mechanical properties, biocompatibility, easy processability, and flexibility. In this study, a PCL/collagen composite membrane with reinforced mechanical properties has been developed. The membrane has a strong composite structure with collagen by utilizing a porous and hydrophilic PCL scaffold, maintaining its integrity even after immersion. The suture retention and mechanical tests demonstrate that compared with the pure collagen membrane, the prepared membrane has a greater tensile strength and twice the modulus of elasticity. Further, the suture retention strength is improved by almost two times. In addition, the membrane remains fully intact on the implant bed in an in vitro corneal defect model. Moreover, the membrane could be tightly sutured to a rabbit corneal defect, progressively achieved epithelialization, and remained unchanged during observation. Overall, the PCL/collagen composite membrane is a promising candidate as a suturable corneal restoration material in clinical keratoplasty.This article is protected by copyright. All rights reserved

show abstract

Synthetic Crosslinker Based on Amino–yne Click to Enhance the Suture Tension of Collagen-Based Corneal Repair Materials

Cited by 11 publications

References 55 publications

Bioinspired, Robust, and Absorbable Cellulose Nanofibrils/Chitosan Filament with Remarkable Cytocompatibility and Wound Healing Properties

Bioinspired, Robust, and Absorbable Cellulose Nanofibrils/Chitosan Filament with Remarkable Cytocompatibility and Wound Healing Properties

Metal-Free Click-Chemistry: A Powerful Tool for Fabricating Hydrogels for Biomedical Applications

Hydrophilic, Porous, Fiber‐Reinforced Collagen‐Based Membrane for Corneal Repair

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