Synthetic cyanoacrylic glue in the prevention of post-operative lymphocele after pelvic lymphadenectomy in patients with uterine malignancies: A prospective, single-blind, preliminary study

Bifulco, Giuseppe; Giampaolino, Pierluigi; Morra, Ilaria; Tommaselli, Giovanni A.; Tarsitano, Francesco; Chiacchio, Gaetano; Nappi, Carmine; Carlo, Costantino Di

doi:10.1016/j.ygyno.2014.06.015

Cited by 10 publications

(9 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the use of Glubran-2 as an adjunct in other areas such as pelvic lymphadenectomy showed reduced lymph production, there was no such benefit shown in our study [24]. The findings of this study were that the use of Glubran-2 did not reduce the risk, volume or duration of seroma.…”

Section: Resultscontrasting

confidence: 74%

See 1 more Smart Citation

A Double-Blinded Prospective Randomised Controlled Trial to Assess the Efficacy of Glubran-2 in Reducing Seroma Formation after a Mastectomy with or without Axillary Dissection

Clement¹,

Shin²,

Hoffmann³

et al. 2017

ABCR

View full text Add to dashboard Cite

Background and Purpose: Seroma formation is a common complication following a mastectomy and axillary surgery. Decreasing the dead space is believed to decrease seroma formation. The aim of this study is to compare the incidence of seroma formation with the use of Glubran-2 versus normal saline during the wound closure in participants undergoing mastectomy with or without axillary dissection. Methods: This multicentre, prospective, double-blinded, randomised controlled trial, enrolled women 18 years of age or older with breast cancer, who were underwent total or partial mastectomy, with or without axillary dissection. Participants were randomised to Glubran-2 or Saline arm. The primary outcome was the volume and duration of wound seroma. Secondary outcome was post-operative wound infection. Results: A total of 76 women were randomised and there was no loss to follow-up or mortality. The total seroma volume was higher in the Glubran-2 arm. The duration of seroma was higher in the mastectomy and axillary dissection group in the Glubran-2 arm (P = 0.69). Elderly and participants with higher BMI had a higher volume of seroma. Post-operative infection rate was higher in the Glubran-2 arm (13.2% vs. 5.6%; P = 0.26). There was no statistically significant difference between the groups. Conclusion: Our study did not show any benefit with the use of Glubran-2 in mastectomy and axillary surgery in reducing the risk of seroma formation. In elderly and obese participants the use of Glubran-2 showed an increase in seroma formation and post-operative wound infection.How to cite this paper:

show abstract

Section: Resultscontrasting

confidence: 74%

“…Glubran-2 polymerises rapidly on contact and firmly adheres to the tissues. It is reported to have good haemostatic and adhesive properties [18]- [24]. This adhesive property can obliterate the dead space after mastectomy and axillary dissection.…”

Section: Introductionmentioning

confidence: 99%

A Double-Blinded Prospective Randomised Controlled Trial to Assess the Efficacy of Glubran-2 in Reducing Seroma Formation after a Mastectomy with or without Axillary Dissection

Clement¹,

Shin²,

Hoffmann³

et al. 2017

ABCR

View full text Add to dashboard Cite

show abstract

“…In these 2 studies, the use of glue was associated with a significant reduction in the number of patients with asymptomatic lymphoceles. 19,22 The results from other studies showed that the glue decreased the rate of asymptomatic lymphocele but not significantly. In a study by Kim et al, the patients were followed and evaluated for lymphocele incidence with computed tomography at 1 and 3 months postoperatively.…”

Section: Biologic Gluesmentioning

confidence: 95%

“…All of these studies reported significant differences between the volumes of drainage in the intervention and control groups. 15,[19][20][21][22] Some studies included cases of advanced-stage ovarian cancer with ascites; the difficulty in differentiating the lymphatic drainage from ascites might have caused the lymphatic drainage result to be less-reliable. 8,15,20 With regard to the effectiveness of biologic glue on reducing lymphocele, 7 studies described the incidence of asymptomatic lymphocele after surgery, which ranged from 1% to 22% in the intervention groups and 16% to 51% in the control groups.…”

Section: Biologic Gluesmentioning

confidence: 99%

“…Table 2 shows inconsistent results in these studies. Tenilli et al 19 used TachoSil Ò and Bifulco et al 22 used Glubran 2, and they applied these glues through laparoscopic and laparotomy approaches, respectively. In these 2 studies, the use of glue was associated with a significant reduction in the number of patients with asymptomatic lymphoceles.…”

Section: Biologic Gluesmentioning

confidence: 99%

See 1 more Smart Citation

Decreasing Lymphoid Fluid Accumulation During Lymph-Node Dissection

TantitamitTanitra

HuangKuan-Gen

HwangLih-Lian

2019

Journal of Gynecologic Surgery

View full text Add to dashboard Cite

Objective: Retroperitoneal lymphadenectomy is a major component of surgical staging for gynecologic malignancies. In addition to controversy surrounding therapeutic value, substantial morbidity has been associated with the procedure. Postoperative lymphatic leakage due to injury to the lymphatic channels is a common complication and can cause severe morbidity, decrease quality of life, and delay subsequent treatment. To minimize or avoid this complication, it is crucial to understand the risk factors and strategies for prevention. This review focuses on possible risk factors and prevention practices to reduce lymphatic leakage and the incidence of lymphocele formation. Materials and Methods: A literature search was performed in PubMed, Medline, Ò and Science Direct. Fiftyeight published English-language articles were obtained. Results: Studies on risk factors have produced widely divergent results. The use of biologic glue is strongly associated with a reduction in lymphatic drainage. Both biologic glue and new energy sources can decrease the incidence of lymphocele, but there is no effect of new devices on the incidence of lymphocele requiring treatment. Conclusions: This review suggests that biologic glue and a new energy device are promising, but more studies are needed. (J GYNECOL SURG 35:129

show abstract

Lymphorrhea

Yang

2024

Supermicrosurgical Lymphaticovenular Anastomosis

View full text Add to dashboard Cite

Synthetic cyanoacrylic glue in the prevention of post-operative lymphocele after pelvic lymphadenectomy in patients with uterine malignancies: A prospective, single-blind, preliminary study

Cited by 10 publications

References 25 publications

A Double-Blinded Prospective Randomised Controlled Trial to Assess the Efficacy of Glubran-2 in Reducing Seroma Formation after a Mastectomy with or without Axillary Dissection

A Double-Blinded Prospective Randomised Controlled Trial to Assess the Efficacy of Glubran-2 in Reducing Seroma Formation after a Mastectomy with or without Axillary Dissection

Decreasing Lymphoid Fluid Accumulation During Lymph-Node Dissection

Lymphorrhea

Contact Info

Product

Resources

About