Synthetic Development and Assessment of Antioxidant Activity of Imino[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile and Its Derivatives

Molecules containing triazolopyrimidine core showed diverse biological activities, including anti-Alzheimer, antidiabetes, anticancer, antimicrobial, antituberculosis, antiviral, antimalarial, anti-inflammatory, anti-parkinsonism activities, and treatment of glaucoma. Triazolopyrimidines have around 8 isomeric structures including the most stable 1,2,4-triazolo[1,5-a] pyrimidine ones. Triazolopyrimidines were obtained by using various chemical reactions, among them a) 1,2,4-triazole nucleus annulation to pyrimidine, b) pyrimidines annulation to 1,2,4-triazole structure, c) 1,2,4-triazolo[l,5-a] pyrimidines rearrangement, and d) pyrimido-tetrazine rearrangement. This review discusses synthetic methods, recent pharmacological actions and drug delivery perspectives of triazolopyrimidines.

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Synthetic Development and Assessment of Antioxidant Activity of Imino[1,2,4]triazolo[1,5-a]pyrimidine-6-carbonitrile and Its Derivatives

Cited by 2 publications

References 37 publications

Functionalized Pyrimidines: Synthetic Approaches and Biological Activities. A Review

Functionalized Pyrimidines: Synthetic Approaches and Biological Activities. A Review

Triazolopyrimidine Derivatives: An Updated Review on Recent Advances in Synthesis, Biological Activities and Drug Delivery Aspects

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