Synthetic efforts toward [3.3.1] bridged bicyclic phloroglucinol natural products

Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins

“…176,177 Application Mukayaima hydration conditions 106 to compound 47 installed the tertiary alcohol of 48 , which served as a protecting group for the alkene. A later step entailed dehydrating this alcohol to regenerate the alkene (highlighted in red).…”

Synthesis of (±) debenzoyl analogs of norsampsones as potential anticancer agents

“…[1][2][3][4][5][6][7] Hypericum sampsonii belongs to the Clusiaceae family which exhibits anticancer activity and has been used as a promising anticancer herb in Taiwan. 8 Very recently, Tian and co-workers 9 isolated norsampsones A-D ( Fig.…”

Hypercohones A–C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens

“…The two types of metabolites were both derived from polyprenylated polycyclic acyphloroglucinols by the further cyclizations of C-3 to the different position of prenyl groups at C-7 ( Figure 1). [10][11][12] The genus Hypericum, occurrs commonly in temperate regions throughout the world, and has been a key plant used in traditional medical systems in many countries. 13 H. cohaerens N. Robson is an endemic plant distributed in Guizhou and Yunnan provinces of China.…”