Synthetic Enzyme‐Catalyzed CO₂ Fixation Reactions

Abstract

In recent years, (de)carboxylases that catalyze reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof‐of‐concept (bio)synthetic CO2 fixation routes for chemical production. However, further progress towards industrial application has been hampered by the thermodynamic constraint that accompanies fixing CO2 to organic molecules. In this Review, biocatalytic carboxylation methods are discussed with emphases on the diverse strategies devised to alleviate the inherent thermodynamic constraints and their application in synthetic CO2‐fixation cascades.

Technologies and perspectives for achieving carbon neutrality

“…Various useful reduction products such as CO, HCOOH, carboxylic acids, and cyclic carbonates have been successfully obtained. 330 , 331 , 332 , 333 However, development in these fields is still in its infancy; considerable effort needs to be dedicated to understanding structural features controlling the catalytic activity and achieving practical catalysts suitable for the conversion of CO 2 to useful chemicals. 334 …”

Prospects and Challenges of Developing Plant‐Derived Snake Antivenin Natural Products: A Focus on West Africa

“…Several of these natural products are easily accessible from commercial vendors or can be synthesised chemically or enzymatically. Given the expanding biocatalytic repertoire, [94–98] it is possible to generate a combinatorial library of structurally diverse analogues of these natural products by exploiting, for example the biocatalytic potential of biosynthetic enzymes [99] . In vitro assays for assessing snake venom neutralising effects of compounds [100] can be adapted for high‐throughput bioactivity evaluation of a large compound library of these natural products.…”

Cu‐Based Organic‐Inorganic Composite Materials for Electrochemical CO2Reduction

“…[6][7][8][9] Various technologies have been developed for selective CO 2 conversion, such as electrocatalysis, [10][11][12][13][14][15][16] photocatalysis, [17][18][19][20][21][22][23][24] thermocatalysis, [25][26][27] and biocatalysis. [28,29] Due to the advantages of mild reaction conditions, wide variety and high energy density of products, electrochemical CO 2 RR driven by renewable energy such as solar energy, wind energy and tide energy, has been considered as an effective and sustainable way to achieve carbon neutrality. [30][31][32][33][34][35][36][37][38] As shown in Table 1, [39,40] the relatively close equilibrium potential of individual product and the competitive hydrogen volution reaction (HER) usually lead to the low selectivity of desirable product in electrochemical CO 2 RR.…”

“…The development of effective strategies to convert CO 2 into high value‐added fuels or chemicals is of great significance for decreasing the CO 2 concentration in the atmosphere and alleviating energy shortage crisis [6–9] . Various technologies have been developed for selective CO 2 conversion, such as electrocatalysis, [10–16] photocatalysis, [17–24] thermocatalysis, [25–27] and biocatalysis [28,29] . Due to the advantages of mild reaction conditions, wide variety and high energy density of products, electrochemical CO 2 RR driven by renewable energy such as solar energy, wind energy and tide energy, has been considered as an effective and sustainable way to achieve carbon neutrality [30–38] .…”