Synthetic estrogens and implantation inhibitors

Antifertility Agents

“…2, and the substitution of a pyrrolidino for the diethylamino group at the para position increased antifertility activity manyfold. Bencze et al (83,84) studied some tetrahydronaphthalenes and found peak antifertility activ ity in basic phenolic ether (XIIa, Fig. 5), which prevented pregnancy in all rats at 20 p.g/kg per day when given on days 1 to 4 after coitus.…”

Ring-D-Bridged Steroid Analogs. V.1 14α,17α-Etheno-15,16-di(trifluoromethyl)pregna-4,15-diene-3,20-dione and 14α,17α-Ethano-15β,16β-di(trifluoromethyl)pregn-4-ene-3,20- dione2

“…Elution with 400 ml of 1:1 hexane-benzene afforded the adduct Ila in a yield of 5.15 g (57'f i as a light yellow semisolid: ""'1" 1785, 1715, 1650 cm"1. The vinyl protons appeared in the nmr spectrum at 5.40 (m), 6.97 (d), and 7.06 (d).…”