Synthetic Factors Governing Access to Tris(β-diketimine) Cyclophanes versus Tripodal Tri-β-aminoenones

Abstract

Tris(β-diketimine) cyclophanes are an important ligand class for investigating cooperative multimetallic interactions of bio-inorganic clusters. Discussed herein are the synthetic factors governing access to tris(β-diketimine) cyclophanes vs. tripodal tri-β-aminoenones. Cyclophanes bearing Me, Et, and MeO cap substituents and β-Me, Et, or Ph arm substituents are obtained, and a modified condensation method produced the α-Me β-Me cyclophane. These operationally simple procedures produce the ligands in gram quantities and in 22-94% yields.

Alkyl backbone variations in common β-diketiminate ligands and applications to N-heterocyclic silylene chemistry

“…26,27 We have very recently introduced a one-pot condensation method to prepare iPrDip nacnacH 28 and this work expands on this backbone modification. We also consider EtAr nacnacH proligands which have been sporadically mentioned in the literature, [29][30][31][32] but in some cases without much synthetic or spectroscopic detail.…”