Synthetic hydrogels formed by thiol–ene crosslinking of vinyl sulfone-functional poly(methyl vinyl ether-alt-maleic acid) with α,ω-dithio-polyethyleneglycol

Abstract

3T3 cells in hydrogel formed by thiol–ene click-crosslinking of vinyl sulfone-functional PMM-CVS with PEG-dithiols.

Development of a Borane–(Meth)acrylate Photo‐Click Reaction

“…Solid-state NMR analysis. In order to prove that the Boron participates to the cross-linking of the materials,w ep erformed aMAS 11 B-NMR analysis in solid state.The spectrum of the material obtained with 2wt. %o ft he NHC-borane DiMeImd-BH 3 and trimethylolpropane triacrylate (TMPTA) as the monomer is displayed in Figure 6.…”

“…[4] In particular,thiol-ene [5][6][7] and thiol-yne [8] reactions have been employed in photopolymerizations.T hey proceed by as tep-growth mechanism involving the radical propagation by addition of photogenerated thiyl radicals-using atype Ior type II photoinitiator-onto av inyl monomer,f ollowed by achain-transfer reaction (Figure 1). Thiol-ene reactions have for example recently been used for the synthesis of hydrogels, [9][10][11][12] bioorganic-functionalized materials, [13,14] polymerdispersed liquid-crystalline phases, [15,16] 3D-printing, [17][18][19] telechelic polyethylenes, [20] etc. However,i ft hiol-ene and -yne reactions have been adopted by many academics,t hiols often smell bad, and are generally too unstable for industrial applications,inparticular in (meth)acrylate formulations because of the competitive Michael addition.…”

Gelatin interpenetration in poly N‐isopropylacrylamide network reduces the compressive modulus of the scaffold: A property employed to mimic hepatic matrix stiffness

“…The stiffness of extracellular matrix (ECM) affects many cellular properties including proliferation, differentiation, morphogenesis and so forth (D'Amore et al, 2018;Saneyasu et al, 2016;Stewart et al, 2018;Zustiak et al, 2016). In the case of the liver, an increase in stiffness of ECM as a result of extensive matrix deposition can be indicative of chronic disease.…”

Development of a Borane–(Meth)acrylate Photo‐Click Reaction

“…• Solid-state NMR analysis. In order to prove that the Boron participates to the cross-linking of the materials, we performed a MAS 11 B-NMR analysis in solid state. The spectrum of the material obtained with 2 wt.% of the NHC-Borane DiMeImd-BH3 and trimethylolpropane triacrylate (TMPTA) as the monomer is displayed in Figure 5.…”

“…The latter could be engaged in a polymerization at stoichiometric ratio (compared to the olefin). The solid-state 11 B MAS NMR spectrum of the resulting material is shown in Figure 6 (black trace) and compared with that of pure solid NHC-Borane (DiMeTriaz-BH3, red trace). Peaks are very similar to those of Figure 5, except for the two most upfield signals.…”