Synthetic Improvements and an Alternative Synthetic Approach to exo‐Dicyclopentadiene‐1‐one: A Useful Building Block for Cyclopentanoids

Abstract

Here, we describe the synthetic improvements to the known compound exo‐dicyclopentadiene‐1‐one (exo‐DCPD‐1‐one). Also, an alternative and efficient synthetic approach to exo‐DCPD‐1‐one was developed in a non‐hazardous manner. All the synthesized compounds here are well‐characterized by NMR analysis. The structure and relative stereochemistry of some key intermediates were confirmed by single‐crystal X‐ray diffraction (XRD) studies. Overall, the synthetic studies described here are useful to prepare exo‐DCPD‐1‐one on a multi‐gram scale in a safe manner. The exo‐DCPD‐1‐one is found to be a useful building block to prepare a wide variety of cyclopentanoids.