Synthetic ion channels in bilayer membranes

Fyles, Thomas M.

doi:10.1039/b603256g

Cited by 317 publications

(176 citation statements)

References 33 publications

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“…Excellent reviews continuously update this field from different points of view. [49][50][51][52][53][54][55][56][57] Specific topics of current interest that became accessible with the introduction of rigid-rod scaffolds include ion selectivity, voltage gating, membrane recognition, ligand gating, blockage, and catalysis. 12 Rigid O-NDI rods 6 ( Fig.…”

Section: Ion Channels and Poresmentioning

confidence: 99%

“…33 However, cation-interactions are intrinsic characteristics of -basic aromatics and thus ubiquitous in natural and synthetic multifunctional architecture. In clear contrast, anion-interactions are theoretically attractive, 54 poorly explored in solution, 55 without reach with biological ion channels and unprecedented in synthetic ion channels. [49][50][51][52][53][54][55][56][57] Our high-level DFT calculations suggested that the global quadrupole moment of the -acidic…”

Section: Ion Channels and Poresmentioning

confidence: 99%

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Synthetic Multifunctional Nanoarchitecture in Lipid Bilayers: Ion Channels, Sensors, and Photosystems

Bhosale

Bollot

et al. 2007

Bulletin of the Chemical Society of Japan

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The creation of functional materials such as ion channels, porous sensors, or smart photosystems depends critically on our ability to assemble sophisticated, error-free and self-repairing nanoarchitecture in a predictable manner. To address these challenging topics, we often used lipid bilayer membranes as compartmentalizing platform and have introduced rigid-rod molecules as privileged scaffolds that bypass all folding problems because they do not fold. This approach provides access to motifs such as rigid-rod barrels, helices, stacks, slides, and wires that can act as smart, stimuli-responsive photosystems, pores, ion channels, hosts, sensors, and catalysts. The selected examples focus on naphthalenediimides (NDIs), a compact, organizable, colorizable, and functionalizable n-semiconductor. This versatile module is used in rigid-rod molecules to mediate transmembrane anion transport by anion-interactions, as sticky -clamp within pore sensors to catch otherwise elusive analytes by aromatic electron donor-acceptor interactions, or in blue, transmembrane -stack architecture to collect and convert photonic energy. These specific examples with multifunctional NDI nanoarchitecture are of help to outline, on the one hand, possibilities to contribute to advanced functional materials such as multianalyte sensors or solar cells and, on the other hand, to keep on wondering about an enormous structural and functional space waiting to be explored.In biology, highest sophistication on both the structural and functional level is accomplished with membrane proteins. Ion channels and pores, for instance, function as stimuli-responsive multianalyte sensors that assure perception of and communication with the outside world.

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Section: Ion Channels and Poresmentioning

confidence: 99%

Section: Ion Channels and Poresmentioning

confidence: 99%

Synthetic Multifunctional Nanoarchitecture in Lipid Bilayers: Ion Channels, Sensors, and Photosystems

Bhosale

Bollot

et al. 2007

Bulletin of the Chemical Society of Japan

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“…Many synthetic supramolecular systems capable of physically transporting chemical signals, such as ions, across lipid bilayer membranes have been reported. [3][4][5][6][7][8][9] However, mimicking signal transduction and amplification processes that occur without physical transfer of matter has proved a considerable challenge for synthetic systems. [10][11][12][13][14][15] Recently, we have shown that a new abiotic mechanism -membrane translocation -can be used for signal transduction across lipid bilayers in artificial systems ( Figure 1a).…”

Section: Introductionmentioning

confidence: 99%

Triggered Release from Lipid Bilayer Vesicles by an Artificial Transmembrane Signal Transduction System

et al. 2017

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The on-demand delivery of drug molecules from nano-scale carriers with spatio-temporal control is a key challenge in modern medicine. Here we show that lipid bilayer vesicles (liposomes) can be triggered to release an encapsulated molecular cargo in response to an external control signal by employing an artificial transmembrane signal transduction mechanism. A synthetic signal transducer embedded in the lipid bilayer membrane acts as a switchable catalyst, catalyzing the formation of surfactant molecules inside the vesicle in response to a change in external pH. The surfactant permeabilises the lipid bilayer membrane to facilitate release of an encapsulated hydrophilic cargo. In the absence of the pH control signal, the catalyst is inactive and the cargo remains encapsulated within the vesicle.

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“…In the past few years, a rich variety of novel artificial nanochannels have been constructed, which is attracting widespread interest because their potential applications in biosensors, drug delivery, nanofluidic devices, etc. 4,5 Experimentally, the integration of stimuli responsive polyelectrolyte brushes into solid-state single nanochannels can create tailor-made nanovalves resembling the functions of sophisticated biological ion channels. 6 The gating mechanism is implemented by collapse-stretching conformational transition of the brushes responsive to pH.…”

Section: Introductionmentioning

confidence: 99%

Translocation of nanoparticles through a polymer brush-modified nanochannel

Cao

Zuo

et al. 2012

Biomicrofluidics

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A basic understanding of the transport mechanisms of nanostructures in a polymer brush-modified nanochannel as well as the brush-nanostructure interactions at molecular level is important to design and fabricate emerging smart nano/ microfluidic channels. In this work, we report coarse-grained molecular dynamics simulations of the translocation of nanoparticles through a cylindrical nanochannel coated with the polymer brush. The effects of the interparticle interaction and grafting density on the distribution and electrokinetic transport of nanoparticles are addressed in detail. Analysis of the distribution and velocity profiles of nanoparticles from the simulations indicate that the location of nanoparticles along the radial direction and their migration velocity are very sensitive to the change of interparticle interaction. We find complicated transport dynamics of nanoparticles under the influence of various grafting densities. The nanoparticles show markedly different translocation behavior upon increasing the grafting density, which depends on the counterion distribution, free room within the brush, nanoparticle-polymer friction, and brush configuration. Our results may serve as a useful starting point for the transport of nanostructures in polymer-modified channels and help to guide the design of novel smart nanofluidic channels for controlling the migration behavior of nanostructures. V C 2012 American Institute of Physics.

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Synthetic ion channels in bilayer membranes

Cited by 317 publications

References 33 publications

Synthetic Multifunctional Nanoarchitecture in Lipid Bilayers: Ion Channels, Sensors, and Photosystems

Synthetic Multifunctional Nanoarchitecture in Lipid Bilayers: Ion Channels, Sensors, and Photosystems

Triggered Release from Lipid Bilayer Vesicles by an Artificial Transmembrane Signal Transduction System

Translocation of nanoparticles through a polymer brush-modified nanochannel

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