Synthetic Melanotropic Peptide Initiates Erections in Men With Psychogenic Erectile Dysfunction

Abstract

Melanotan-II is a potent initiator of erections in men with psychogenic erectile dysfunction and has manageable side effects at a dose of 0.025 mg./kg.

Vardenafil Increases Penile Rigidity and Tumescence in Men with Erectile Dysfunction after a Single Oral Dose

“…While this study did not measure the ability of the men to perform sexual intercourse, the quality of rigidity at >60% has some correlation with the ability to perform intercourse. The Rigiscan™ device is used for the pharmacodynamic evaluation of investigational treatments of ED [9, 10, 11]. However, Rigiscan™ measurements evaluate only a limited aspect of overall sexual performance and the data from pharmacodynamic observations like the present need to be confirmed by further real–life pharmacotherapeutic observations [12].…”

Design of cyclic peptides with biological activities from biologically active peptides: the case of peptide modulators of melanocortin receptors

“…. This compound has been used very extensively worldwide to study melanotropin biological activity, and also has been in clinical trials for erectile dysfunction …”

Adventures in peptides and science with students! the joys of research

“…Among other findings, we demonstrated that MT‐I (and later MT‐II) led to pigmentation throughout the body without sun and that this hormone‐induced pigment could reduce UV radiation‐induced DNA damage in humans. Equally exciting was the finding that MT‐II, in a double blind, placebo controlled, clinical trial could lead to erectile function in men with non‐organic erectile dysfunction when given peripherally. These compounds may soon be in clinical medicine.…”