Synthetic Methods

Facile synthesis of (polyfluoro)alkanesulfinyl 4-isoxazolines: a stepwise solvent- and catalyst-free approach or a one-pot process in water

“…41 On the other hand, incorporation of fluorine atoms would profoundly influence the electronic, lipophilic, and steric parameters of an organic molecule, which has led to valuable methodologies toward the synthesis of various organofluorine compounds. 42,43 Given the importance of 4-isoxazolines, sulfoxides and organofluorine compounds and based on our previous research on perfluoroalkyl sulfoxides, [44][45][46][47][48] we are intrigued by the synthesis of potential biologically interesting polyfluoroalkanesulfinyl 4-isoxazolines, especially in a green manner. With the growing public concern over environmental disruption, the synthetic community all over the world is endeavouring to develop more sustainable and greener synthetic protocols.…”

“…41 On the other hand, incorporation of fluorine atoms would profoundly influence the electronic, lipophilic, and steric parameters of an organic molecule, which has led to valuable methodologies toward the synthesis of various organofluorine compounds. 42,43…”