“…Pyrazole is a versatile ring among heterocyclic compounds as pyrazole compounds are involved in plethora of applications, including; industries, medications, pharmaceutics, agriculture, polymers, luminophores, dyes, etc. 15 Pyrazole containing compounds have various therapeutic and pharmaceutical properties and represent important building blocks for, insectoacaricidal, 16 antibacterial, 17 antidepressant, analgesic, antiviral, anticancer, antioxidant, anti-HIV, COX-2 inhibitor, antiinflammatory, antiproliferative drugs. [18][19][20][21][22][23][24][25][26] Due to multifaceted applications of the pyrazole derivatives, a quite good number of methods for the attainment of the heterocycle have been developed using Al2O3/clay (montmorillonite K10 31 , Amberlyst-70 32 , polymer bound PTSA 33 , silica-supported sulphuric acid (H2SO4•SiO2) 34 , Sc(OTf)3 35 , sulphamic acid 36 as catalysts.…”