2020
DOI: 10.2174/2211352517666191022103831
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Synthetic Methods and Antimicrobial Perspective of Pyrazole Derivatives: An Insight

Abstract: Background: Newly emerging microbial infections and development of resistance against cutting-edge therapeutics has created deep necessity for innovative and robust medicinal agents. Small ring heterocycles, such as pyrazole and its derivatives have been acknowledged to possess myriad biological properties and presence of pyrazole in clinics like celecoxib, phenylbutazone (anti-inflammatory), CDPPB (antipsychotic), rimonabant (anti-obesity), antipyrine, difenamizole (analgesic), fipronil (broad-spectrum insect… Show more

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Cited by 17 publications
(8 citation statements)
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“…Pyrazole is a versatile ring among heterocyclic compounds as pyrazole compounds are involved in plethora of applications, including; industries, medications, pharmaceutics, agriculture, polymers, luminophores, dyes, etc. 15 Pyrazole containing compounds have various therapeutic and pharmaceutical properties and represent important building blocks for, insectoacaricidal, 16 antibacterial, 17 antidepressant, analgesic, antiviral, anticancer, antioxidant, anti-HIV, COX-2 inhibitor, antiinflammatory, antiproliferative drugs. [18][19][20][21][22][23][24][25][26] Due to multifaceted applications of the pyrazole derivatives, a quite good number of methods for the attainment of the heterocycle have been developed using Al2O3/clay (montmorillonite K10 31 , Amberlyst-70 32 , polymer bound PTSA 33 , silica-supported sulphuric acid (H2SO4•SiO2) 34 , Sc(OTf)3 35 , sulphamic acid 36 as catalysts.…”
Section: Template For Synthesis Thiemementioning
confidence: 99%
“…Pyrazole is a versatile ring among heterocyclic compounds as pyrazole compounds are involved in plethora of applications, including; industries, medications, pharmaceutics, agriculture, polymers, luminophores, dyes, etc. 15 Pyrazole containing compounds have various therapeutic and pharmaceutical properties and represent important building blocks for, insectoacaricidal, 16 antibacterial, 17 antidepressant, analgesic, antiviral, anticancer, antioxidant, anti-HIV, COX-2 inhibitor, antiinflammatory, antiproliferative drugs. [18][19][20][21][22][23][24][25][26] Due to multifaceted applications of the pyrazole derivatives, a quite good number of methods for the attainment of the heterocycle have been developed using Al2O3/clay (montmorillonite K10 31 , Amberlyst-70 32 , polymer bound PTSA 33 , silica-supported sulphuric acid (H2SO4•SiO2) 34 , Sc(OTf)3 35 , sulphamic acid 36 as catalysts.…”
Section: Template For Synthesis Thiemementioning
confidence: 99%
“…They can exist in three tautomeric forms due to the π-electrons shifting into the heterocycle ring [ 1 ]. Pzs show a large number of applications due to the aromatic character of the heterocycle core that makes them resistant to oxidation, reduction, and acid or basic hydrolysis [ 2 ]. For this reason, Pz derivatives are useful as agrochemicals, such as insecticides, fungicides, and herbicides [ 3 , 4 ]; or as dyes [ 5 ], sunscreen materials [ 6 ], analytical reagents [ 7 ], and powerful ligands in coordination chemistry [ 8 ].…”
Section: Introductionmentioning
confidence: 99%
“…The synthesis of these structural frameworks has gained substantial interest in recent years, with the goal of developing additional pharmacophores with robust biological profiles [11,12] . Clubbing pyrazole and thiazole functionality into single strucutral entity resulted in to promising anti‐cancer, anti‐inflammatory, analgesic, anti‐tubercular, anti‐alzheimer, anti‐diabetic, anti‐microbial, anti‐mycobacterial and EP 1 receptor antagonists activtiy [10–20] . The benzothiazoles have been reported to play a vital role in enhancing the biological properties [21–23] .…”
Section: Introductionmentioning
confidence: 99%
“…[11,12] Clubbing pyrazole and thiazole functionality into single strucutral entity resulted in to promising anti-cancer, anti-inflammatory, analgesic, anti-tubercular, anti-alzheimer, anti-diabetic, anti-microbial, anti-mycobacterial and EP 1 receptor antagonists activtiy. [10][11][12][13][14][15][16][17][18][19][20] The benzothiazoles have been reported to play a vital role in enhancing the biological properties. [21][22][23] In relvence to biological studies molecular simulations are gaining importance.…”
Section: Introductionmentioning
confidence: 99%
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