Synthetic microfluidic paper: high surface area and high porosity polymer micropillar arrays

Hansson, Jonas; Yasuga, Hiroki; Haraldsson, Tommy; Wijngaart, Wouter van der

doi:10.1039/c5lc01318f

Cited by 57 publications

(58 citation statements)

References 24 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…63,64 Even though hundreds of PDMS replicas can be made from a single microfabricated master, there is a high entry barrier because of the need for familiarity with mask design and cleanroom processes to make the master. Whereas some of the cost barriers can be overcome by using lower-resolution photomasks made of flexible transparency films that cost only tens of dollars, the long cycle times between making photomasks and completing the cleanroom-based fabrication remain.…”

Section: Fabricationmentioning

confidence: 99%

See 1 more Smart Citation

Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits

et al. 2018

View full text Add to dashboard Cite

Microfluidics offer economy of reagents, rapid liquid delivery, and potential for automation of many reactions, but often require peripheral equipment for flow control. Capillary microfluidics can deliver liquids in a pre-programmed manner without peripheral equipment by exploiting surface tension effects encoded by the geometry and surface chemistry of a microchannel. Here, we review the history and progress of microchannel-based capillary microfluidics spanning over three decades. To both reflect recent experimental and conceptual progress, and distinguish from paper-based capillary microfluidics, we adopt the more recent terminology of capillaric circuits (CCs). We identify three distinct waves of development driven by microfabrication technologies starting with early implementations in industry using machining and lamination, followed by development in the context of micro total analysis systems (μTAS) and lab-on-a-chip devices using cleanroom microfabrication, and finally a third wave that arose with advances in rapid prototyping technologies. We discuss the basic physical laws governing capillary flow, deconstruct CCs into basic circuit elements including capillary pumps, stop valves, trigger valves, retention valves, and so on, and describe their operating principle and limitations. We discuss applications of CCs starting with the most common usage in automating liquid delivery steps for immunoassays, and highlight emerging applications such as DNA analysis. Finally, we highlight recent developments in rapid prototyping of CCs and the benefits offered including speed, low cost, and greater degrees of freedom in CC design. The combination of better analytical models and lower entry barriers (thanks to advances in rapid manufacturing) make CCs both a fertile research area and an increasingly capable technology for user-friendly and high-performance laboratory and diagnostic tests.

show abstract

Section: Fabricationmentioning

confidence: 99%

“…44,88 Synthetic microfluidic paper with well-controlled arrays of interlocked micropillars was developed in polymer and demonstrated to provide improved performance compared to conventional porous materials. 64 Hydrogels 90 and superabsorbent polymers 91,92 were also used as pumps to drive capillary-driven flow.…”

Section: Capillary Pumpmentioning

confidence: 99%

Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits

et al. 2018

View full text Add to dashboard Cite

show abstract

“…It is widely used for medical diagnostics at home (pregnancy test) or in a laboratory testing. The technology involves the transportation of fluids (e.g., urine) through capillary beds, fragments of porous paper, microstructured polymers, or sintered polymers (Hansson et al, 2016).…”

Section: Lateral Flow Testmentioning

confidence: 99%

Antibody Engineering for Pursuing a Healthier Future

et al. 2017

View full text Add to dashboard Cite

Since the development of antibody-production techniques, a number of immunoglobulins have been developed on a large scale using conventional methods. Hybridoma technology opened a new horizon in the production of antibodies against target antigens of infectious pathogens, malignant diseases including autoimmune disorders, and numerous potent toxins. However, these clinical humanized or chimeric murine antibodies have several limitations and complexities. Therefore, to overcome these difficulties, recent advances in genetic engineering techniques and phage display technique have allowed the production of highly specific recombinant antibodies. These engineered antibodies have been constructed in the hunt for novel therapeutic drugs equipped with enhanced immunoprotective abilities, such as engaging immune effector functions, effective development of fusion proteins, efficient tumor and tissue penetration, and high-affinity antibodies directed against conserved targets. Advanced antibody engineering techniques have extensive applications in the fields of immunology, biotechnology, diagnostics, and therapeutic medicines. However, there is limited knowledge regarding dynamic antibody development approaches. Therefore, this review extends beyond our understanding of conventional polyclonal and monoclonal antibodies. Furthermore, recent advances in antibody engineering techniques together with antibody fragments, display technologies, immunomodulation, and broad applications of antibodies are discussed to enhance innovative antibody production in pursuit of a healthier future for humans.

show abstract

“…The microstructured surfaces are made from Ostemer 220 (Mercene Labs, Stockholm, Sweden), a UV-curing Off-Stoichiometry-Thiol-Ene (OSTE) resin, with excellent lithographic patterning, previously used to create complex slanted structures 29 . The samples are manufactured as follows.…”

Section: Sample Preparationmentioning

confidence: 99%

Droplet leaping governs microstructured surface wetting

et al. 2019

Self Cite

View full text Add to dashboard Cite

Microstructured surfaces that control the direction of liquid transport are not only ubiquitous in nature, but they are also central to technological processes such as fog/water harvesting, oil-water separation, and surface lubrication. However, a fundamental understanding of the initial wetting dynamics of liquids spreading on such surfaces is lacking. Here, we show that three regimes govern microstructured surface wetting on short time scales: spread, stick, and contact line leaping. The latter involves establishing a new contact line downstream of the wetting front as the liquid leaps over specific sections of the solid surface. Experimental and numerical investigations reveal how different regimes emerge in different flow directions during wetting of periodic asymmetrically microstructured surfaces. These insights improve our understanding of rapid wetting in droplet impact, splashing, and wetting of vibrating surfaces and may contribute to advances in designing structured surfaces for the mentioned applications.

show abstract

Synthetic microfluidic paper: high surface area and high porosity polymer micropillar arrays

Cited by 57 publications

References 24 publications

Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits

Capillary microfluidics in microchannels: from microfluidic networks to capillaric circuits

Antibody Engineering for Pursuing a Healthier Future

Droplet leaping governs microstructured surface wetting

Contact Info

Product

Resources

About