Synthetic Mussel Adhesive Proteins

Masilamani, Divakar; Goldberg, Ina; Salerno, Alessandro G.; Oleksiuk, Mary A.; Unger, Peter D.; Piascik, Deborah A.; Bhattacharjee, Himangshu R.

doi:10.1007/978-1-4615-3844-8_20

Cited by 5 publications

(1 citation statement)

References 18 publications

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“…Many of these enzymatic reactions are catalyzed by the phenolase group of enzymes, which carry out oxidation reactions in the production of a byssal thread protein [5–7]. Likewise, a final set of reactions that lead to the formation of the attachment plaque and the finished byssus are also enzymatically catalyzed, oxidation‐type reactions [7–9].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of candidate chemicals for preventing attachment of zebra mussels (Dreissena polymorpha)

Cope

Bartsch

Marking

1997

Enviro Toxic and Chemistry

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Abstract-Forty-seven chemicals having potential for preventing the attachment of zebra mussels Dreissena polymorpha were identified and tested. For each chemical, 15 zebra mussels (5-8-mm shell length) in each of two replicates and six treatments were exposed for 48 h followed by a 48-h postexposure period in untreated water. Eleven of the chemicals inhibited the reattachment of zebra mussels after the 48-h exposure; eight had EC50 values ranging from 0.4 to 5.4 mg/L, and three had EC50 values ranging from 19.4 to 29.0 mg/L. Based on an analysis of chemical cost, solubility in water, anticipated treatment concentrations, and potential hazards to humans or the environment, three of the most promising chemicals, all antioxidants, (butylated hydroxyanisole [BHA], tert-butylhydroquinone, and tannic acid) were tested on nontarget fish (bluegill, Lepomis macrochirus; channel catfish, Ictalurus punctatus; and rainbow trout, Oncorhynchus mykiss). These chemicals were not selectively toxic to zebra mussels; only the tests with bluegill and BHA and with channel catfish and tannic acid had 48-h LC50 values greater than the concentrations effective for preventing the reattachment of zebra mussels. Although the attachment of zebra mussels can be prevented with selected antioxidants, an alternative formulation should be investigated to minimize effects on nontarget organisms, such as fish.

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Section: Introductionmentioning

confidence: 99%

Efficacy of candidate chemicals for preventing attachment of zebra mussels (Dreissena polymorpha)

Cope

Bartsch

Marking

1997

Enviro Toxic and Chemistry

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Life behind cell walls: paradigm lost, paradigm regained

Lamport

2001

CMLS, Cell. Mol. Life Sci.

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This review of the living cell wall and its protein components is in two parts. The first is anecdotal. A personal account spanning over 40 years research may perhaps be an antidote to one stereotypical view of scientists as detached and humorless. The second part deals with the meaning of function, particularly as it applies to hydroxyproline-rich glycoproteins. Function is a difficult word to define objectively. However, with help from such luminaries as Humpty Dumpty: "A word means what I want it to mean, neither more nor less," and Wittgenstein: "Giving examples of usage ... is the only way to talk about meaning," it is possible to construct a ziggurat representing increasingly complex levels of organization from molecular structure to ecology. Forty years ago I suggested that hydroxyproline-rich structural proteins played a key role in cell wall functioning. But because the bulk of the wall is carbohydrate, there has been an understandable resistance to paradigm change. Expansins, paradoxically, contribute greatly to this resistance because their modus operandi as cell-wall-loosening proteins is based on the idea that they break hydrogen bonds between polysaccharide chains allowing slippage. However, this view is not consistent with the recent discovery [Grobe et al. (1999) Eur. J. Biochem 263: 33-40] that beta-expansins may be proteases, as it implies that the extensin network is not a straightjacket but a substrate for expansin in muro. Such a direct role for extensins in both negative and positive regulation of cell expansion and elongation may constitute a major morphogenetic mechanism operating at all levels of plant growth and development.

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