Synthetic organic chemicals (flame retardants and pesticides) with neurotoxic potential induced behavioral impairment on zebrafish (Danio rerio): a non-invasive approach for neurotoxicology

Assessment of eco-toxic effects of commonly used water disinfectant on zebrafish (Danio rerio) swimming behaviour and recovery responses: an early-warning biomarker approach

“…Magalhaes et al ( 2007 ) reported similar behaviour anomalies on zebrafish under NaOCl treatments, where the swimming activity decreased with increasing NaOCl concentration. In our previous studies, we also noticed a correlation between declined swimming activity of zebrafish with chemical concentrations (Zhao et al 2020 ; Poopal et al 2021 ; Ren et al 2021 ). Declined swimming strength under (360 h) NaOCl treatments reveals the avoidance behaviour of zebrafish.…”

“…The significance of these endpoints could increase the ecological significance of risk assessment procedures. Behaviour anomalies associated with toxicant treatment can recover once fish are introduced to a toxicant free environment; thus, recovery responses are recognised as an assisting parameter in behavioural toxicology (Ren et al 2021 ).…”

IR-Based Novel Device for Real-Time Online Acquisition of Fish Heart ECG Signals

“…to develop techniques to monitor or assess all of the water quality impacts in a direct way. Moreover, the practical limitations such as a lack of detection of different effects (synergistic and antagonistic) on nontarget organisms, requirements of experts and high costs for analyzing chemicals in analytical techniques, and expensive in maintaining sensors have resulted in the development of biological-based online monitoring systems for monitoring water quality . Real-time online biological response monitoring systems for water quality assessment and monitoring began during the early 1970s. , Bioresponses directly affect stress factors that mainly depend on the magnitude, frequency, and exposure duration .…”

“…Likewise, deltamethrin (DM) is an insecticide (pyrethroid group) and is widely used to control pests of crops and aquatic organisms; with the phasing out of toxic organophosphate insecticides, different types of pyrethroids are being promoted in agricultural countries . These chemical groups (metals and pesticides) can bioaccumulate in tissues and cause toxic effects on aquatic organisms. ,, The researchers conducted extensive studies on their (common water pollutants) environmental fate and toxicity to aquatic organisms. However, most studies have focused on the killing of test animals to evaluate the toxic effects of these common water contaminants.…”

The Effect of Different Repeated Doses of Cypermethrin on the Behavioral and Histological Alterations in the Brain of Rabbits (Oryctolagus cuniculi)

“…Insecticides are associated with harmful effects on body organs, including wide-ranging brain damage. The insecticides reflect their neurotoxic effects mostly by gliosis, vague changes of glial tissues to central nervous system (CNS) injuries such as reported multiple system atrophy, prion disease, and multiple sclerosis (Igho and Afoke 2014;Ren et al 2021). These discoveries were similar to investigations in which cerebellar and cerebral changes occurred due to insecticide treatment in rats (Gupta 2012).…”