Synthetic polymer–tissue adhesion using an ultrasonic scalpel

Yamamoto, Kenji; Kimura, Tsuyoshi; Nam, Kwangwoo; Funamoto, Seiichi; Ito, Yukiko; Shiba, Kanako; Katoh, Ayako; Shimizu, Shigeru; Kurita, Kimio; Higami, Tetsuya; Masuzawa, Toru; Kishida, Akio

doi:10.1007/s00464-010-1357-7

Cited by 9 publications

(10 citation statements)

References 13 publications

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“…The ionizing treatment altered the PE surface from hydrophobic to relatively hydrophilic by introducing mainly oxygen (Yamamoto et al 2011). The contact angle between liquid-solid interfaces is a good indicator of adsorption because it increases the capacity of the liquid to spread, thereby decreasing the contact angle (Rubin 2004).…”

Section: Contact Angle Measurements Of Ionized Filmsmentioning

confidence: 99%

Two Different Processes to Obtain Antimicrobial Packaging Containing Natural Oils

Solano

Gante

2011

Food Bioprocess Technol

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In this study, antimicrobial packaging materials were developed by incorporating known concentrations (w/w) of essentials oils of oregano (Origanum vulgare) and thyme (Thymus vulgaris) into low-density polyethylene (LDPE), suitable for use as food packaging, via two different methods: ionizing treatment and directly by extrusion. The mechanical, barrier, and antimicrobial properties of the packaging were evaluated against the following foodborne pathogens: Salmonella typhimurium, Listeria monocytogenes, and Escherichia coli O157:H7. The results demonstrate that films developed by extrusion incorporating 4% (w/w) of essential oils had a higher inhibitory effect than those obtained using the ionizing treatment. The packaging developed by extrusion containing 1% (w/w) showed a positive inhibitory effect, while those obtained by the ionizing treatment had no inhibitory effect against any of the test microorganisms. The incorporation of essential oils on the LDPE films generated a plasticizer effect, whereas the ones obtained by means of ionizing treatment did significantly affect the barrier properties of the films. The results of this study showed that plantderived essential oils could be incorporated in active films for food packaging.

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Section: Contact Angle Measurements Of Ionized Filmsmentioning

confidence: 99%

Two Different Processes to Obtain Antimicrobial Packaging Containing Natural Oils

Solano

Gante

2011

Food Bioprocess Technol

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“…In a previous work, using polymeric films as model materials, we found that functional groups and physical properties dominated material–tissue adhesion . These findings were based on the structural and physical properties of the material, which had bonded to tissue upon the application of heat and mechanical vibration generated by the blade of an ultrasonically activated scalpel .…”

Section: Introductionmentioning

confidence: 83%

“…The monomer was chosen based on the results of our previous study . The purchased acrylic acid (AA) (Wako Chemicals, Tokyo, Japan), methacrylic acid (MA) (Wako Chemicals, Tokyo, Japan), 4‐vinylbenzoic acid (VBA) (Kohjin, Tokyo, Japan), hydroxyethyl acrylate (HEA) (Wako Chemicals, Tokyo, Japan), and hydroxyethyl methacrylate (HEMA) (Wako Chemicals, Tokyo, Japan) were all distilled to eliminate moisture and the inhibitors and then kept in a cool and dark environment.…”

Section: Methodsmentioning

confidence: 99%

“…We focused on achieving adhesion between an implant and a native tissue by means of an ultrasonically activated scalpel that applies heat and pressure to both components . This technique, which was originally developed to stop bleeding by coagulating the proteins in the tissue, is very effective for the adhesion of materials such as polymers and metals to tissue because the heat and pressure applied to the materials and the tissue enables bonding by a mechanism similar to that of protein coagulation as mentioned above .…”

Section: Introductionmentioning

confidence: 99%

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Adhesion between polymer surface modified by graft polymerization and tissue during surgery using an ultrasonically activated scalpel device

Nam

Iwata

Kimura

et al. 2014

J of Applied Polymer Sci

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In the field of surgery, achieving adhesion between a polymer implant and tissue poses a challenge considering that suturing is not appropriate for the stability of such implants. An ultrasonically activated scalpel that generates heat by mechanical vibration and promotes adhesion between a polymer implant and native tissue by pressing the two materials together has very good potential for application in the field. To determine the type of polymer that is suitable for the purpose, we investigated polyethylene (PE) and polystyrene (PS) films, the surfaces of which were activated by corona discharge. Graft polymerization was then performed on the corona‐treated surfaces to vary their properties. The corona‐treated PE and PS films grafted with poly(acrylic acid), poly(methacrylic acid), poly(vinyl benzylacrylic acid), and poly(hydroxylethyl acrylate), respectively, adhered to the tissue when the ultrasonically activated scalpel was applied. The heat generated by the mechanical vibration and the applied pressure enabled the carboxyl or hydroxyl groups to bond with the proteins in the extracellular matrix. We therefore concluded that it was possible to integrate this technique in the development of new types of polymer devices that could be stably implanted in a living body. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40885.

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“…In the second stage at 65°C the resulting prepolymer is reacted with TPED or HMB, at the equimolar ratio of -NCO to -OH groups using DBTDL as a catalyst, getting macroinitiators in MEK solution, appropriately urethane-tetraphenylethane (TPE-PU-TPE) or bromourethane (MBP-PU-MBP) containing 0 wt% content of -NCO groups 14 . The TPE--PU-TPE macroinitiator synthesis process is presented by the following scheme: (5) where: R denotes part of the structure coming from TPE-PU-TPE or MBP-PU-MBP.…”

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confidence: 99%

Comparison of Hydrolytic Resistance of Polyurethanes and Poly(Urethanemethacrylate) Copolymers in Terms of their Use as Polymer Coatings in Contact with the Physiological Liquid

Król

Chmielarz

Król

et al. 2014

Polish Journal of Chemical Technology

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PU elastomers were synthesized using MDI, PTMO, butane-1,4-diol or 2,2,3,3-tetrafl uorobutane-1,4-diol. Using the same diisocyanate and polyether reagents urethane segments were prepared, to be inserted in the poly(urethane--methacrylate) copolymers. Bromourethane or tetraphenylethane-urethane macroinitiators were used as transitional products reacting with MMA according to the ARGET ATRP. 1H and 13C NMR spectral methods, as well as DSC and TGA thermal methods, were employed to confi rm chemical structures of synthesised elastomers and copolymers. To investigate the possibility of using synthesized polymers as biomaterials a research on keeping them in physiological liquid at 37°C was performed. A loss in weight and ability to sorption of water was determined and by using GPC the molecular weight changes were compared. Additionally, changes in the thermal properties of the samples after exposure in physiological liquid were documented using both the TGA and DSC methods. The studies of surface properties (confocal microscopy and SFE) of the obtained polymers were performed. The structure of the polymer chains was defi ned by NMR. Possible reasons of hydrolysis were discussed, stating that new copolymers are more resistant and polar biomaterials can be less interesting than elastomers.

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Synthetic polymer–tissue adhesion using an ultrasonic scalpel

Abstract: Both polar functional groups and adequate thermal characteristics are necessary for polymers to bond with tissues. These findings should be useful for the development of novel polymers that can be bonded to living tissues with UAS treatment, which can be applied for endoscopic surgery.

Cited by 9 publications

References 13 publications

Two Different Processes to Obtain Antimicrobial Packaging Containing Natural Oils

Two Different Processes to Obtain Antimicrobial Packaging Containing Natural Oils

Adhesion between polymer surface modified by graft polymerization and tissue during surgery using an ultrasonically activated scalpel device

Comparison of Hydrolytic Resistance of Polyurethanes and Poly(Urethanemethacrylate) Copolymers in Terms of their Use as Polymer Coatings in Contact with the Physiological Liquid

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