Synthetic polymeric biomaterials for wound healing: a review

Abstract

Wounds are of a variety of types and each category has its own distinctive healing requirements. This realization has spurred the development of a myriad of wound dressings, each with specific characteristics. It is unrealistic to expect a singular dressing to embrace all characteristics that would fulfill generic needs for wound healing. However, each dressing may approach the ideal requirements by deviating from the ‘one size fits all approach’, if it conforms strictly to the specifications of the wound and the patient. Indeed, a functional wound dressing should achieve healing of the wound with minimal time and cost expenditures. This article offers an insight into several different types of polymeric materials clinically used in wound dressings and the events taking place at cellular level, which aid the process of healing, while the biomaterial dressing interacts with the body tissue. Hence, the significance of using synthetic polymer films, foam dressings, hydrocolloids, alginate dressings, and hydrogels has been reviewed, and the properties of these materials that conform to wound-healing requirements have been explored. A special section on bioactive dressings and bioengineered skin substitutes that play an active part in healing process has been re-examined in this work.

Tunable hydrogels for mesenchymal stem cell delivery: Integrin-induced transcriptome alterations and hydrogel optimization for human wound healing

“…Another advantage of this system is that the mechanical properties of the synthetic matrices can be tailored to mimic soft tissues of interest, here in the range of healthy dermis for wound healing applications. Our research is just one example of how hydrogels can be “tuned” for a variety of different therapeutic applications and afford the potential to be molded to any shape of interest for filling defects within injured tissues …”

“…Our research is just one example of how hydrogels can be "tuned" for a variety of different therapeutic applications and afford the potential to be molded to any shape of interest for filling defects within injured tissues. 66,67 Integrins are integral membrane proteins that allow cells to sense and interact with their external environment, comprised mainly of ECM glycoproteins and neighboring cells. 68 There are at least 24 integrin heterodimers, each with a unique binding specificity.…”

Regeneración Del Órgano Cutáneo Mediante Ingeniería De Tejidos

“…Entre los materiales no biodegradables es común el uso de derivados de polietileno, politetrafluoroetileno, polimetilacrilatos, poliacrilamidas, poliéteres, polisiloxanos, poliuretanos, polietilenglicol entre otros [20]. Este tipo de materiales tienen ventajas tales como la no inmunogenicidad, buena reproductibilidad, adecuadas propiedades mecánicas y formas diseñadas a la medida [18].…”

Therapeutic compression materials and wound dressings for chronic venous insufficiency: A comprehensive review

“…Recently, Hussain et al systematically reviewed and reported a number of convincing evidences for bioactive materials embedded polymer‐based chronic wound healing modalities, as well as the latest and innovative therapeutic strategies for management of chronic nonhealing wounds (Hussain, Thu, Shuid, Katas, & Hussain, ; Shao et al, ). Related studies also introduced technical solutions in development of different biomaterials used in wounds healings (Mir et al, ; Murray, West, Cowin, & Farrugia, ; Pop & Almquist, ). Figure illustrates the classification of bioactive agent‐based dressings applied to treat CVI.…”