Synthetic Polysaccharides. II. Fractionation of Polyglucose¹

On the Structure of 1,2,3,6-Tetra-O-acetyl-β-D-glucose

“…The latter substance has more recently been obtained both by Lewis-acid catalyzed isomerizations2 of I, as well as by hydrolysis, followed by partial acetylation, of l,2,3-tri-0-acetyl-4,6-benzylidene-0-D-glucose. 3 The isomerized acetate, although then similar in melting point to the known 2,3,4,6tetra-O-acetyl-0-D-glucose, showed a mixed melting point depression with the latter,1•6 and therefore did not have its free hydroxyl group at Cl. Also, the isomerized tetraacetate could be tosylated to give a product which, after cautious saponification, yielded a mono-O-p-toluenesulfonate different from the known 3-0-p-toluenesulfonyl-D-glucose of Freudenberg and I vers,4 an observation which was interpreted as eliminating the possibility of a free hydroxyl at C3 in the isomerized acetate.…”

The partition of solutes between buffer solutions and solutions containing hyaluronic acid

“…Polyglucose. Synthetic polyglucose was a present from Dr P. T. Mora (Mora, 1958). The sample had been precipitated by ethanol between 62-5 and 72-5% (v/v).…”

Polymerization of chondroitin sulfate and its stimulatory effect on cartilage regeneration; a bioactive material for cartilage regeneration

“…We aimed to address these problems by polymerizing CS. There are a number of studies on the synthesis of oligo-and poly-saccharides by chemical [18][19][20][21][22] and enzymatic methods [23][24][25]. There are also patents on producing water-insoluble polysaccharides by using a cross-linking agent [26] and/or by polycondensation of saccharides in the presence of carboxylic acid catalysts at reduced pressure [27].…”