Synthetic routes to aminodinitrotoluenes

Nielsen, Arnold T.; Henry, Ronald A.; Norris, William P.; Atkins, Ronald L.; Moore, Donald W.; Lepie, Albert H.; Coon, Clifford L.; Spanggord, Ronald J.; Son, Dong-Hwan

doi:10.1021/jo01328a037

Cited by 33 publications

(8 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, many derivatives have been synthesized with the objective of discovering new pharmacological agents such as immunosupressants 202 , fungicides 203 and agents for the prevention of nerve cell damage 204 . Anthranilic acid has also been used in the synthesis of polycyclic aromatic hydrocarbons, such as dicyclooctabiphenylenes 205 , phenanthrenequinones 206 , fluorenones 207 , benzonorbornadienes 208 , toluenes 209 , naphthalenes and anthracenes 210 and benzyne-furan adducts 211 . Most of these syntheses are based upon the formation of benzyne after diazotization of anthranilic acid and the subsequent addition to a diene.…”

Section: Scheme 47mentioning

confidence: 99%

The chemistry of isatins: a review from 1975 to 1999

Silva¹,

Garden²,

Pinto³

2001

J. Braz. Chem. Soc.

858

447

View full text Add to dashboard Cite

Isatinas (1H-indol-2,3-diona) são compostos de grande versatilidade sintética, podendo ser utilizados na obtenção de diversos sistemas heterociclos, como derivados indólicos e quinolínicos, o que as tornam importantes matérias-primas na síntese de fármacos. Isatinas também têm sido detectadas em tecidos de mamíferos, o que tem despertado o interesse em seu estudo como moduladores em diversos processos bioquímicos. Os avanços na aplicação de isatinas em síntese orgânica, bem como na compreensão de seus efeitos biológicos e farmacológicos nos últimos vinte e cinco anos encontram-se relatados nesta revisão e seus respectivos materiais suplementares.Isatins (1H-indole-2,3-dione) are synthetically versatile substrates, where they can be used for the synthesis of a large variety of heterocyclic compounds, such as indoles and quinolines, and as raw material for drug synthesis. Isatins have also been found in mammalian tissue and their function as a modulator of biochemical processes has been the subject of several discussions. The advances in the use of isatins for organic synthesis during the last twenty-five years, as well as a survey of its biological and pharmacological properties are reported in this review and in the accompanying supplementary information.

show abstract

Section: Scheme 47mentioning

confidence: 99%

The chemistry of isatins: a review from 1975 to 1999

Silva¹,

Garden²,

Pinto³

2001

J. Braz. Chem. Soc.

858

447

View full text Add to dashboard Cite

show abstract

“…It is worth mentioning that water was indispensable in the hydrolysis reaction of carbamates for its nucleophilic behaviour. [17][18][19] Among the various alcohol-water mixtures, involving methanol, ethanol, propanol, isopropyl alcohol, and glycol, glycol-water (3 : 1 in volume) could promote the reaction up to 85.9 % yield at 958C.…”

Section: Synthesis Of Polynitrostilbenesmentioning

confidence: 99%

Synthesis and Thermal Stability of New Polynitrostilbenes

Wei

et al. 2015

Aust. J. Chem.

View full text Add to dashboard Cite

show abstract

“…Currently there are methodologies that allow selective reduction of the nitro group in TNT. [39][40][41][42] …”

Section: Transformations Of the Nitro Groupmentioning

confidence: 99%

Synthesis of benzannelated five-membered heteroaromatic compounds from 2,4,6-trinitrotoluene

Bastrakov¹,

Старосотников²,

Шевелев

2008

Arkivoc

View full text Add to dashboard Cite

Methods for the synthesis of five-membered benzannelated heterocyclic compounds from the military explosive 2,4,6-trinitrotoluene (TNT) are summarised. The general approach concerns the transformation of the TNT methyl group followed by either intramolecular substitution of the ortho-nitro group or regioselective substitution of the ortho-nitro group by an appropriate nucleophile and subsequent cyclization.

show abstract

Synthetic routes to aminodinitrotoluenes

Cited by 33 publications

References 7 publications

The chemistry of isatins: a review from 1975 to 1999

The chemistry of isatins: a review from 1975 to 1999

Synthesis and Thermal Stability of New Polynitrostilbenes

Synthesis of benzannelated five-membered heteroaromatic compounds from 2,4,6-trinitrotoluene

Contact Info

Product

Resources

About