Synthetic, spectral as well as in vitro antimicrobial studies on some bismuth(III) bis(N,N‐dialkyldithiocarbamato) alkylenedithiophosphates

Chauhan, H. P. S.; Bakshi, Abhilasha; Bhatiya, Sumit

doi:10.1002/aoc.1609

Cited by 24 publications

(8 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The motivation for the present study arose from recent observations of remarkable antimicrobial activities, specifically against Gram-positive bacteria, exhibited by related phosphanegold(I) thiocarbamate compounds, i.e. Ph 3 PAu[SC(OR)=N(tol-p)], for R = Me, Et and iPr [29], and by the knowledge that other metal dithiocarbamates have been reported to exhibit antimicrobial activity [30][31][32].…”

Section: Chemistrymentioning

confidence: 99%

In vitro antibacterial and time-kill evaluation of phosphanegold(I) dithiocarbamates, R3PAu[S2CN(iPr)CH2CH2OH] for R = Ph, Cy and Et, against a broad range of Gram-positive and Gram-negative bacteria

et al. 2014

View full text Add to dashboard Cite

The in vitro antibacterial activity of a series of phosphanegold(I) dithiocarbamates, R 3 PAu[S 2 CN (iPr)CH 2 CH 2 OH] where R = Ph (2), Cy (3) and Et (4), against 25 strains of Gram-positive and Gram-negative bacteria were determined through the disk diffusion method, the determination of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) and by time-kill assay. Compounds 2 and 3 have been shown to be specifically active against the tested Gram-positive bacteria, with MIC values ranging from 7.81 to 125 μg/ml. Compound 4 has a broadspectrum activity against 24 strains of Gram-positive and Gram-negative bacteria, with MIC values ranging from 0.98 to 1,000 μg/ml. Noteworthy was that 4, with a very low MIC value of 0.98 μg/ml, is particularly effective against methicillin-resistant Staphylococcus aureus (MRSA) and Bacillus sp., as effective as the standard antibiotic ciprofloxacin. In time-kill studies, the bacteriostatic and bactericidal activities of the tested compounds towards susceptible strains were similar to their characteristics determined by MBC/MIC ratios. In the time-kill assay, 2 and 3 showed only bactericidal activity towards the susceptible strains tested, whereas 4 revealed varying degrees of bactericidal and bacteriostatic activities, results indicating different antibacterial mechanisms are involved.

show abstract

Section: Chemistrymentioning

confidence: 99%

In vitro antibacterial and time-kill evaluation of phosphanegold(I) dithiocarbamates, R3PAu[S2CN(iPr)CH2CH2OH] for R = Ph, Cy and Et, against a broad range of Gram-positive and Gram-negative bacteria

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Despite this, bismuth compounds have been widely used in medicinal fields for centuries because of low toxicity and high effectiveness in the treatment of various microbial infections . Bismuth compounds have also shown anticancer activities in addition to antimicrobial activities …”

Section: Introductionmentioning

confidence: 99%

Synthesis and structural characterization of new bioactive ligands and their Bi(III) derivatives

Raheel

Imtiaz‐ud‐Din

Andleeb

et al. 2016

Applied Organom Chemis

View full text Add to dashboard Cite

Five new carboxylic acid precursors bearing thiourea group and their corresponding bismuth(III) complexes were synthesized and characterized using CHNS and inductively coupled plasma analyses and infrared and NMR ( 1 H, 13 C) spectroscopies. Single-crystal X-ray diffraction analysis was also carried out for one of the precursors. The behaviour of the compounds was bioassayed for antibacterial, antifungal, antioxidant and enzyme (lipoxygenase, α-glycosidase and anti-urease) inhibition activities. It is concluded that the interaction of the compounds with bismuth enhances both the antimicrobial and enzyme inhibition activities. The synthesized compounds may prove to be good therapeutic agents.

show abstract

“…In addition, the ─CH 2 ─ and N─CH 2 ─ protons of dithiocarbamate moiety in the spectra are observed at their expected positions and no appreciable shift is observed in their positions as compared to the corresponding sodium salt of free dithiocarbamate moiety …”

Section: Resultsmentioning

confidence: 92%

Syntheses, characterization, antibacterial activity and molecular modelling of phenylantimony(III) heteroleptic derivatives containing substituted oximes and piperidine dithiocarbamate

Beniwal

Chhimpa

Gaur

et al. 2017

Applied Organom Chemis

View full text Add to dashboard Cite

Six new heteroleptic phenylantimony(III) derivatives containing substituted oximes and dithiocarbamate moieties of the type (where R = ─C 6 H 5 , X = ─CH 3 (2a); R = ─C 6 H 4 CH 3 , X = ─CH 3 (2b); R = ─C 6 H 4 Cl, X = ─CH 3 (2c); R = ─C 6 H 4 Br, X = ─CH 3 (2d); R = ─C 6 H 4 OH, X = ─H (2e); R(X)C = (2f)) have been synthesized by the reactions of phenylantimony(III) dichloride with the sodium salt of substituted oximes and dithiocarbamate moiety in unimolar ratio with stirring in dichloromethane. All these newly synthesized derivatives have been characterized using physicochemical and elemental analyses. Structures have been proposed on the basis of infrared, 1 H NMR, 13 C NMR and LC-MS spectral studies and molecular modelling. In these derivatives the oxime behaves in an unidentate manner whereas dithiocarbamate behaves in a monofunctional anisobidentate manner. Pseudo-trigonal bipyramidal (ψ-TBP) geometry around the antimony metal centre is proposed for these phenylantimony(III) heteroleptic derivatives. The geometry of a representative complex has been optimized through molecular modelling. These newly synthesized derivatives were screened against Bacillus subtilis (Gram-positive) and Escherichia coli (Gram-negative) bacteria to evaluate their antibacterial potential. The structureactivity relationship for antibacterial activity among the four derivatives 2a, 2c, 2e and 2f is discussed.

show abstract

Synthetic, spectral as well as in vitro antimicrobial studies on some bismuth(III) bis(N,N‐dialkyldithiocarbamato) alkylenedithiophosphates

Cited by 24 publications

References 32 publications

In vitro antibacterial and time-kill evaluation of phosphanegold(I) dithiocarbamates, R3PAu[S2CN(iPr)CH2CH2OH] for R = Ph, Cy and Et, against a broad range of Gram-positive and Gram-negative bacteria

In vitro antibacterial and time-kill evaluation of phosphanegold(I) dithiocarbamates, R3PAu[S2CN(iPr)CH2CH2OH] for R = Ph, Cy and Et, against a broad range of Gram-positive and Gram-negative bacteria

Synthesis and structural characterization of new bioactive ligands and their Bi(III) derivatives

Syntheses, characterization, antibacterial activity and molecular modelling of phenylantimony(III) heteroleptic derivatives containing substituted oximes and piperidine dithiocarbamate

Contact Info

Product

Resources

About