2021
DOI: 10.2174/1871520621666201207092836
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Synthetic Spirocyclohexadienones as New Anti-Migratory Compounds in Triple- Negative Breast Cancer Cell Migration

Abstract: Background: Triple-negative BC is the most aggressive type of breast cancer and its lack of responsiveness to conventional therapies requires screening of new chemical entities. Anti-migratory compounds are promising to treat metastatic cancer since they inhibit one of the main steps of the metastatic cascade. Spirocyclic compounds are non-conventional structures used as building blocks for the synthesis of biologically active molecules and considered interesting structures in the search for exploration of ne… Show more

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“…Finally, we were intrigued by the potential biological activities of these synthesized chiral spirocyclic enones and investigated their anticancer properties without further modifications, as described in Figure . After initial screening of cell viability using the cell counting kit-8 (CCK-8) assay, compounds 3a , 3e , 3j, and 4d exhibited high antiproliferative activity (see the Supporting Information for details).…”
Section: Resultsmentioning
confidence: 99%
“…Finally, we were intrigued by the potential biological activities of these synthesized chiral spirocyclic enones and investigated their anticancer properties without further modifications, as described in Figure . After initial screening of cell viability using the cell counting kit-8 (CCK-8) assay, compounds 3a , 3e , 3j, and 4d exhibited high antiproliferative activity (see the Supporting Information for details).…”
Section: Resultsmentioning
confidence: 99%