Synthetic strategies for purine nucleoside analogs

Elgemeie, Galal H.; Mohamed-Ezzat, Reham A.

doi:10.1016/b978-0-12-821783-2.00002-9

New Strategies Targeting Cancer Metabolism 2022

DOI: 10.1016/b978-0-12-821783-2.00002-9

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Synthetic strategies for purine nucleoside analogs

Galal H. Elgemeie

Reham A. Mohamed-Ezzat²

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2023

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Crystal structure of 5-(β-D-glucopyranosylthio)-N-(4-methylphenyl)-1,3,4-thiadiazol-2-amine

et al. 2023

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In the structure of the title compound, C15H19N3O5S2, the bond lengths at the linking sulfur atom are significantly different [1.7473 (17) and 1.811 (2) Å], and the angle at the exocyclic nitrogen atom is wide at 128.45 (18)°. The interplanar angle between the tolyl and thiadiazole rings is 9.2 (1)°. The complex hydrogen-bonding pattern, involving five donors and five acceptors, can be broken down into a one-dimensional ribbon parallel to the b axis, involving hydrogen bonds of the sugar residues only, and a two-dimensional layer structure parallel to the ab plane, based on the N—H...O and O—H...N hydrogen bonds.

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Crystal structure of 5-(β-D-glucopyranosylthio)-N-(4-methylphenyl)-1,3,4-thiadiazol-2-amine

et al. 2023

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Synthetic strategies for purine nucleoside analogs

Cited by 1 publication

References 143 publications

Crystal structure of 5-(β-D-glucopyranosylthio)-N-(4-methylphenyl)-1,3,4-thiadiazol-2-amine

Crystal structure of 5-(β-D-glucopyranosylthio)-N-(4-methylphenyl)-1,3,4-thiadiazol-2-amine

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