Synthetic strategies for the construction of C3-fluorinated oxindoles

Abstract

C3-fluorinated oxindoles are important scaffolds known to demonstrate various biological properties. As the bio-isosteres of oxindoles, these compounds have shown tremendous potential in drug research discovery programs. Besides, they also...

Heteroannulation of Arynes with α-Bromodifluorohydroxamates: An Efficient and General Approach to Access 2,2-Difluoro Indoxyls

“…However, no general report exists for the synthesis of 2,2-difluoro indoxyls, a potential bioisostere of isatin/3-oxindoles . In contrast, its regioisomeric analogue, i.e., 3,3-difluoro oxindoles, has received tremendous attention from synthetic chemists for their construction owing to their significance as bioisosteres in pharmaceuticals (Figure , eq 1) . Therefore, a general approach to access 2,2-difluoro indoxyls is highly desirable.…”