Synthetic Studies of Strigol and Its Analogs

Structural modifications of strigol analogs. Influence of the B and C rings on the bioactivity of the germination stimulant GR24

“…The tricyclic ABC part requires a five-step synthesis from 1-indanone, whereas the 7-phenyl-7-butyrolactone is commercially available. Therefore, 7, which is also very active on Striga asiatica seeds (Brooks et al, 1987), is an attractive alternative for GR24 and should be further investigated as potential control agent for parasitic weeds, of the genera Striga and Orobanche.…”

Improved Synthesis of Methyl 3-oxo-2,6,6-trimethylcyclohex-1-ene-1-carboxylate, an A-ring intermediate for (±)strigol

“…Strigol(1) is a highly potent seed germination stimulant for witchweed, a harmful parasitic plant that attacks numerous graminaceous crops. Several partial and total syntheses of (±) strigol had been reported [1][2][3][4][5] .…”