Synthetic studies towards naturally occurring aporpinones: asymmetric synthesis of 1′-deshydroxymethyl analogues of aporpinone A, aporpinone B and 4′-hydroxyaporpinone A

Abstract

Herein, we disclose the asymmetric total synthesis of 1'-deshydroxymethyl analogues of naturally occurring aporpinone A, aporpinone B, and 4'-hydroxyaporpinone A having γ-Z-alkylidene butenolide framework. Bimetallic (Pd-Cu) cascade cyclization on properly...