Synthetic Study for Two 2H‐Chromenic Acids, 8‐Chlorocannabiorcichromenic Acid and Mycochromenic Acid.

Abstract

Two 2H-chromenes having a fully substituted benzene ring, 8-chlorocannabiorcichromene (1) and mycochromenic acid (2), were synthesized by a condensation of salicylaldehydes with isopropylidenemalonate or the thermal cyclization of corresponding propargyl ethers.

Brevianamides and Mycophenolic Acid Derivatives from the Deep-Sea-Derived Fungus Penicillium brevicompactum DFFSCS025

“…Compounds 5 – 10 were identified as 6-(3-carboxybutyl)-7-hydroxy-5-methoxy -4-methylphthalan-1-one [ 18 ], 7-hydroxy-6-[2-hydroxy-2-(2-methyl-5-oxotetrahydro-2-furyl) ethyl]-5-methoxy-4-methyl-1-phthalanone [ 10 ], 5-hydroxy-7-methoxy-4 –methylphtalide [ 19 ], mycochromenic acid [ 10 , 20 ], (−)-brevianamide C [ 21 ], and (+)-brevianamide A [ 22 ], respectively.…”